TY - JOUR
T1 - Self-assembled nanocages for hydrophilic guest molecules
AU - Jones, Marie-Christine
AU - Tewari, P.
AU - Blei, C.
AU - Hales, K.
AU - Pochan, D.J.
AU - Leroux, J.-C.
PY - 2006/11/15
Y1 - 2006/11/15
N2 - Reverse polymeric micelles are obtained following the association of polymeric amphiphiles in apolar media. To this date, reports of pharmaceutical applications for such micelles have been scarce, mainly because these systems have been studied in solvents that are not suitable for medical use. Here, alkylated star-shaped poly(glycerol methacrylate) polymers have been proposed in the design of oil-soluble reverse polymeric micelles. Micellar behavior was studied in various apolar solvents, including ethyl oleate, a pharmaceutically acceptable vehicle. The polymers were shown to assemble into spherical nanostructures (
AB - Reverse polymeric micelles are obtained following the association of polymeric amphiphiles in apolar media. To this date, reports of pharmaceutical applications for such micelles have been scarce, mainly because these systems have been studied in solvents that are not suitable for medical use. Here, alkylated star-shaped poly(glycerol methacrylate) polymers have been proposed in the design of oil-soluble reverse polymeric micelles. Micellar behavior was studied in various apolar solvents, including ethyl oleate, a pharmaceutically acceptable vehicle. The polymers were shown to assemble into spherical nanostructures (
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-33751015748&partnerID=8YFLogxK
U2 - 10.1021/ja065462c
DO - 10.1021/ja065462c
M3 - Article
AN - SCOPUS:33751015748
SN - 0002-7863
VL - 128
SP - 14599
EP - 14605
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 45
ER -