Projects per year
Abstract
Many glycoproteins are intimately linked to the onset and progression of numerous heritable or acquired diseases of humans, including cancer. Indeed the recognition of specific glycoproteins remains a significant challenge in analytical method and diagnostic development. Herein, a hierarchical bottom-up route exploiting reversible covalent interactions with boronic acids and so-called click chemistry for the fabrication of glycoprotein selective surfaces that surmount current antibody constraints is described. The self-assembled and imprinted surfaces, containing specific glycoprotein molecular recognition nanocavities, confer high binding affinities, nanomolar sensitivity, exceptional glycoprotein specificity and selectivity with as high as 30 fold selectivity for prostate specific antigen (PSA) over other glycoproteins. This synthetic, robust and highly selective recognition platform can be used in complex biological media and be recycled multiple times with no performance decrement.
Original language | English |
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Pages (from-to) | 5114-5119 |
Number of pages | 6 |
Journal | Chemical Science |
Volume | 6 |
Issue number | 9 |
Early online date | 17 Jun 2015 |
DOIs | |
Publication status | Published - 1 Sept 2015 |
ASJC Scopus subject areas
- Chemistry(all)
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Dive into the research topics of 'Selective glycoprotein detection through covalent templating and allosteric click-imprinting'. Together they form a unique fingerprint.Projects
- 1 Finished
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Boronic Acids for Dye Sensitised Solar Cells
Fossey, J.
Engineering & Physical Science Research Council
23/04/12 → 22/04/14
Project: Research