SECURE study: Incidentally detected MGUS patients have comparable depression and anxiety rates to UK general population

Elizabeth S. Knight; Sherin Varghese; Constantinos Koshiaris; Sulgi Byun; Richard Brouwer; Sæmundur Rögnvaldsson; Guy Pratt; Stella Bowcock; Ross Sadler; Aimee Maloney; Vicki M. Gamble; Roderick Oakes; Grace Killingsworth; Patricia Nicholls; Supratik Basu; Jacqueline Stones; Earnest Heartin; Victoria Garvey; Sarah J. Essex; Saranne Hufton; Karthik Ramasamy

doi:10.1111/bjh.70245

SECURE study: Incidentally detected MGUS patients have comparable depression and anxiety rates to UK general population

Elizabeth S. Knight^*
, Sherin Varghese
, Constantinos Koshiaris
, Sulgi Byun
, Richard Brouwer
, Sæmundur Rögnvaldsson
, Guy Pratt
, Stella Bowcock
, Ross Sadler
, Aimee Maloney
, Vicki M. Gamble
, Roderick Oakes
, Grace Killingsworth
, Patricia Nicholls
, Supratik Basu
, Jacqueline Stones
, Earnest Heartin
, Victoria Garvey
, Sarah J. Essex
, Saranne Hufton

Karthik Ramasamy

^*Corresponding author for this work

Cancer Research UK Clinical Trials Unit

Research output: Contribution to journal › Letter › peer-review

Original language	English
Number of pages	4
Journal	British Journal of Haematology
Early online date	12 Nov 2025
DOIs	https://doi.org/10.1111/bjh.70245
Publication status	E-pub ahead of print - 12 Nov 2025

Keywords

depression
psychological distress
anxiety
GAD‐7
monoclonal gammopathy of undetermined significance (MGUS)
intolerance of uncertainty scale (IUS‐27)
prospective cohort study
health anxiety inventory (HAI)
PHQ‐9

Access to Document

10.1111/bjh.70245Licence: Creative Commons: Attribution (CC BY)

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Cite this

Knight, E. S., Varghese, S., Koshiaris, C., Byun, S., Brouwer, R., Rögnvaldsson, S., Pratt, G., Bowcock, S., Sadler, R., Maloney, A., Gamble, V. M., Oakes, R., Killingsworth, G., Nicholls, P., Basu, S., Stones, J., Heartin, E., Garvey, V., Essex, S. J., ... Ramasamy, K. (2025). SECURE study: Incidentally detected MGUS patients have comparable depression and anxiety rates to UK general population. British Journal of Haematology. Advance online publication. https://doi.org/10.1111/bjh.70245

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title = "SECURE study: Incidentally detected MGUS patients have comparable depression and anxiety rates to UK general population",

keywords = "depression, psychological distress, anxiety, GAD‐7, monoclonal gammopathy of undetermined significance (MGUS), intolerance of uncertainty scale (IUS‐27), prospective cohort study, health anxiety inventory (HAI), PHQ‐9",

author = "Knight, \{Elizabeth S.\} and Sherin Varghese and Constantinos Koshiaris and Sulgi Byun and Richard Brouwer and S{\ae}mundur R{\"o}gnvaldsson and Guy Pratt and Stella Bowcock and Ross Sadler and Aimee Maloney and Gamble, \{Vicki M.\} and Roderick Oakes and Grace Killingsworth and Patricia Nicholls and Supratik Basu and Jacqueline Stones and Earnest Heartin and Victoria Garvey and Essex, \{Sarah J.\} and Saranne Hufton and Karthik Ramasamy",

year = "2025",

month = nov,

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doi = "10.1111/bjh.70245",

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journal = "British Journal of Haematology",

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Knight, ES, Varghese, S, Koshiaris, C, Byun, S, Brouwer, R, Rögnvaldsson, S, Pratt, G, Bowcock, S, Sadler, R, Maloney, A, Gamble, VM, Oakes, R, Killingsworth, G, Nicholls, P, Basu, S, Stones, J, Heartin, E, Garvey, V, Essex, SJ, Hufton, S & Ramasamy, K 2025, 'SECURE study: Incidentally detected MGUS patients have comparable depression and anxiety rates to UK general population', British Journal of Haematology. https://doi.org/10.1111/bjh.70245

TY - JOUR

T1 - SECURE study

T2 - Incidentally detected MGUS patients have comparable depression and anxiety rates to UK general population

AU - Knight, Elizabeth S.

AU - Varghese, Sherin

AU - Koshiaris, Constantinos

AU - Byun, Sulgi

AU - Brouwer, Richard

AU - Rögnvaldsson, Sæmundur

AU - Pratt, Guy

AU - Bowcock, Stella

AU - Sadler, Ross

AU - Maloney, Aimee

AU - Gamble, Vicki M.

AU - Oakes, Roderick

AU - Killingsworth, Grace

AU - Nicholls, Patricia

AU - Basu, Supratik

AU - Stones, Jacqueline

AU - Heartin, Earnest

AU - Garvey, Victoria

AU - Essex, Sarah J.

AU - Hufton, Saranne

AU - Ramasamy, Karthik

PY - 2025/11/12

Y1 - 2025/11/12

KW - depression

KW - psychological distress

KW - anxiety

KW - GAD‐7

KW - monoclonal gammopathy of undetermined significance (MGUS)

KW - intolerance of uncertainty scale (IUS‐27)

KW - prospective cohort study

KW - health anxiety inventory (HAI)

KW - PHQ‐9

U2 - 10.1111/bjh.70245

DO - 10.1111/bjh.70245

M3 - Letter

SN - 0007-1048

JO - British Journal of Haematology

JF - British Journal of Haematology

ER -