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Abstract
Extracellular proteins are a subject of intense interest because of their essential roles in bacterial lifestyles. However, several terms related to secretion are used confusingly in the literature, and this is a topical issue in genomics and proteomics. Defining a secreted protein as actively translocated via a secretion system, here, we put into perspective that homologous translocation systems can result in radically different subcellular localizations of a secreted protein. We propose using standardized nomenclature for secretion systems from type I to type Vill for Gram-negative bacteria only, whereas the terms 'Sec' (secretion), 'Tat' (twin-arginine translocation), 'FEA' (flagella export apparatus), 'FPE' (fimbrilin-protein exporter), 'holin' (hole forming) and 'Wss' (WXG100 secretion system) should be applied to translocation systems across the cytoplasmic membrane of both Gram-positive and Gram-negative bacteria. Finally, we discuss why the term 'exoproteome' should be favoured over 'secretome' when describing the subset of proteins present in the extracellular milieu.
Original language | English |
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Pages (from-to) | 139-145 |
Number of pages | 7 |
Journal | Trends in Microbiology |
Volume | 17 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2009 |
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Dive into the research topics of 'Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue'. Together they form a unique fingerprint.Projects
- 1 Finished
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Understanding Events at the Cell Surface During Autotransporter Biogenesis
Henderson, I. & Overduin, M.
10/09/07 → 9/04/11
Project: Research Councils