TY - JOUR
T1 - Sarcoplasmic reticulum functin and muscle contractile character following fatiguing exercise in humans
AU - Hill, CA
AU - Thompson, MW
AU - Ruell, PA
AU - Thom, JM
AU - White, Michael
PY - 2001/3/15
Y1 - 2001/3/15
N2 - 1. This study examined the alterations in calcium release, calcium uptake and calcium ATPase activity of skeletal muscle sarcoplasmic reticulum in response to a bout of intense dynamic knee extensor exercise, and the relationship between these changes and alterations in muscle contractile characteristics in the human quadriceps. 2. In biopsy samples taken from the vastus lateralis, sarcoplasmic reticulum calcium release and calcium uptake were significantly depressed (P <0.01 and 0.05, respectively) immediately following the exercise with no alteration in the sacroplasmic reticulum Ca2+-ATPase activity. 3. A 33 % reduction in the maximum voluntary isometric torque was found following the exercise, with reduced torques from electrically evoked isometric contractions at low frequencies of stimulation (10 and 20 Hz) but not at higher frequencies (50 and 100 Hz). 4. The depressed calcium release was correlated (P
AB - 1. This study examined the alterations in calcium release, calcium uptake and calcium ATPase activity of skeletal muscle sarcoplasmic reticulum in response to a bout of intense dynamic knee extensor exercise, and the relationship between these changes and alterations in muscle contractile characteristics in the human quadriceps. 2. In biopsy samples taken from the vastus lateralis, sarcoplasmic reticulum calcium release and calcium uptake were significantly depressed (P <0.01 and 0.05, respectively) immediately following the exercise with no alteration in the sacroplasmic reticulum Ca2+-ATPase activity. 3. A 33 % reduction in the maximum voluntary isometric torque was found following the exercise, with reduced torques from electrically evoked isometric contractions at low frequencies of stimulation (10 and 20 Hz) but not at higher frequencies (50 and 100 Hz). 4. The depressed calcium release was correlated (P
UR - http://www.scopus.com/inward/record.url?scp=0035868808&partnerID=8YFLogxK
U2 - 10.1111/j.1469-7793.2001.0871h.x
DO - 10.1111/j.1469-7793.2001.0871h.x
M3 - Article
C2 - 11251066
SN - 1469-7793
VL - 531
SP - 871
EP - 878
JO - The Journal of Physiology
JF - The Journal of Physiology
IS - 3
ER -