Sarcopenia in inflammatory bowel disease: a narrative overview

Amritpal Dhaliwal, Jonathan I. Quinlan, Kellie Overthrow, Carolyn Greig, Janet M. Lord, Matthew J. Armstrong, Sheldon C. Cooper*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
152 Downloads (Pure)

Abstract

Malnutrition is a common condition encountered in patients with inflammatory bowel disease (IBD) and is often associated with sarcopenia (the reduction of muscle mass and strength) which is an ever‐growing consideration in chronic diseases. Recent data suggest the prevalence of sarcopenia is 52% and 37% in Crohn’s disease and ulcerative colitis, respectively, however it is chal-lenging to fully appreciate the prevalence of sarcopenia in IBD. Sarcopenia is an important consideration in the management of IBD, including the impact on quality of life, prognostication, and treatment such as surgical interventions, biologics and immunomodulators. There is evolving research in many chronic inflammatory states, such as chronic liver disease and rheumatoid arthritis, whereby interventions have begun to be developed to counteract sarcopenia. The purpose of this review is to evaluate the current literature regarding the impact of sarcopenia in the management of IBD, from mechanistic drivers through to assessment and management.

Original languageEnglish
Article number656
JournalNutrients
Volume13
Issue number2
DOIs
Publication statusPublished - 17 Feb 2021

Bibliographical note

Funding Information:
Funding: This research was funded by NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham.

Funding Information:
Acknowledgments: Doctors A. Dhaliwal and J. Quinlan are funded by the NIHR Birmingham BRC. The views expressed.

Keywords

  • Exercise
  • Inflammatory bowel disease
  • Muscle mass
  • Nutrition
  • Sarcopenia

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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