Safety of coronary artery bypass surgery during therapeutic oral anticoagulation

KEJ Airaksinen; F Biancari; P Karjalainen; R Mikkola; K Kuttila; P Porela; T Laitio; Gregory Lip

doi:10.1016/j.thromres.2011.05.021

Safety of coronary artery bypass surgery during therapeutic oral anticoagulation

KEJ Airaksinen, F Biancari, P Karjalainen, R Mikkola, K Kuttila, P Porela, T Laitio, Gregory Lip

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Abstract

Introduction: Therapeutic (international normalized ratio, INR 2.0-3.5) oral anticoagulation (TOAC) is assumed to increase perioperative bleeding complications and a standard recommendation is to discontinue warfarin before coronary bypass grafting (CABG). Materials and Methods: To assess the safety of TOAC we retrospectively analyzed consecutive patients (n = 270) with long-term warfarin therapy referred for CABG in two centers where TOAC strategy is employed. The main in-hospital outcomes of interest were death, stroke, acute myocardial infarction, new onset renal failure, resternotomy, and their composite. In the TOAC group of 103 patients CABG was performed during therapeutic oral anticoagulation and in the control group (81 patients) preoperative INR was lowered to a subtherapeutic (

Original language	English
Pages (from-to)	435-439
Number of pages	5
Journal	Thrombosis Research
Volume	128
Issue number	5
DOIs	https://doi.org/10.1016/j.thromres.2011.05.021
Publication status	Published - 1 Nov 2011

Keywords

bleeding
complications
Coronary artery bypass surgery
anticoagulation

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10.1016/j.thromres.2011.05.021

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title = "Safety of coronary artery bypass surgery during therapeutic oral anticoagulation",

abstract = "Introduction: Therapeutic (international normalized ratio, INR 2.0-3.5) oral anticoagulation (TOAC) is assumed to increase perioperative bleeding complications and a standard recommendation is to discontinue warfarin before coronary bypass grafting (CABG). Materials and Methods: To assess the safety of TOAC we retrospectively analyzed consecutive patients (n = 270) with long-term warfarin therapy referred for CABG in two centers where TOAC strategy is employed. The main in-hospital outcomes of interest were death, stroke, acute myocardial infarction, new onset renal failure, resternotomy, and their composite. In the TOAC group of 103 patients CABG was performed during therapeutic oral anticoagulation and in the control group (81 patients) preoperative INR was lowered to a subtherapeutic (",

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T1 - Safety of coronary artery bypass surgery during therapeutic oral anticoagulation

AU - Airaksinen, KEJ

AU - Biancari, F

AU - Karjalainen, P

AU - Mikkola, R

AU - Kuttila, K

AU - Porela, P

AU - Laitio, T

AU - Lip, Gregory

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Introduction: Therapeutic (international normalized ratio, INR 2.0-3.5) oral anticoagulation (TOAC) is assumed to increase perioperative bleeding complications and a standard recommendation is to discontinue warfarin before coronary bypass grafting (CABG). Materials and Methods: To assess the safety of TOAC we retrospectively analyzed consecutive patients (n = 270) with long-term warfarin therapy referred for CABG in two centers where TOAC strategy is employed. The main in-hospital outcomes of interest were death, stroke, acute myocardial infarction, new onset renal failure, resternotomy, and their composite. In the TOAC group of 103 patients CABG was performed during therapeutic oral anticoagulation and in the control group (81 patients) preoperative INR was lowered to a subtherapeutic (

AB - Introduction: Therapeutic (international normalized ratio, INR 2.0-3.5) oral anticoagulation (TOAC) is assumed to increase perioperative bleeding complications and a standard recommendation is to discontinue warfarin before coronary bypass grafting (CABG). Materials and Methods: To assess the safety of TOAC we retrospectively analyzed consecutive patients (n = 270) with long-term warfarin therapy referred for CABG in two centers where TOAC strategy is employed. The main in-hospital outcomes of interest were death, stroke, acute myocardial infarction, new onset renal failure, resternotomy, and their composite. In the TOAC group of 103 patients CABG was performed during therapeutic oral anticoagulation and in the control group (81 patients) preoperative INR was lowered to a subtherapeutic (

KW - bleeding

KW - complications

KW - Coronary artery bypass surgery

KW - anticoagulation

U2 - 10.1016/j.thromres.2011.05.021

DO - 10.1016/j.thromres.2011.05.021

M3 - Article

VL - 128

SP - 435

EP - 439

JO - Thrombosis Research

JF - Thrombosis Research

IS - 5

ER -

Safety of coronary artery bypass surgery during therapeutic oral anticoagulation

Abstract

Keywords

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