Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains

N A Gingles; J E Alexander; A Kadioglu; P W Andrew; A Kerr; T J Mitchell; E Hopes; P Denny; S Brown; H B Jones; S Little; G C Booth; W L McPheat

doi:10.1128/IAI.69.1.426-434.2001

Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains

N A Gingles, J E Alexander, A Kadioglu, P W Andrew, A Kerr, T J Mitchell, E Hopes, P Denny, S Brown, H B Jones, S Little, G C Booth, W L McPheat

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.

Original language	English
Pages (from-to)	426-34
Number of pages	9
Journal	Infection and Immunity
Volume	69
Issue number	1
DOIs	https://doi.org/10.1128/IAI.69.1.426-434.2001
Publication status	Published - Jan 2001

Keywords

Animals
Bacteremia
Genetic Predisposition to Disease
H-2 Antigens
Lung
Mice
Mice, Inbred Strains
Neutrophils
Pneumococcal Infections
Species Specificity

Access to Document

10.1128/IAI.69.1.426-434.2001

Cite this

Gingles, N. A., Alexander, J. E., Kadioglu, A., Andrew, P. W., Kerr, A., Mitchell, T. J., Hopes, E., Denny, P., Brown, S., Jones, H. B., Little, S., Booth, G. C., & McPheat, W. L. (2001). Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains. Infection and Immunity, 69(1), 426-34. https://doi.org/10.1128/IAI.69.1.426-434.2001

@article{ba6914d44b4746d68d5361a44c27b712,

title = "Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains",

abstract = "From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.",

keywords = "Animals, Bacteremia, Genetic Predisposition to Disease, H-2 Antigens, Lung, Mice, Mice, Inbred Strains, Neutrophils, Pneumococcal Infections, Species Specificity",

author = "Gingles, {N A} and Alexander, {J E} and A Kadioglu and Andrew, {P W} and A Kerr and Mitchell, {T J} and E Hopes and P Denny and S Brown and Jones, {H B} and S Little and Booth, {G C} and McPheat, {W L}",

year = "2001",

month = jan,

doi = "10.1128/IAI.69.1.426-434.2001",

language = "English",

volume = "69",

pages = "426--34",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "1",

}

Gingles, NA, Alexander, JE, Kadioglu, A, Andrew, PW, Kerr, A, Mitchell, TJ, Hopes, E, Denny, P, Brown, S, Jones, HB, Little, S, Booth, GC & McPheat, WL 2001, 'Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains', Infection and Immunity, vol. 69, no. 1, pp. 426-34. https://doi.org/10.1128/IAI.69.1.426-434.2001

TY - JOUR

T1 - Role of genetic resistance in invasive pneumococcal infection

T2 - identification and study of susceptibility and resistance in inbred mouse strains

AU - Gingles, N A

AU - Alexander, J E

AU - Kadioglu, A

AU - Andrew, P W

AU - Kerr, A

AU - Mitchell, T J

AU - Hopes, E

AU - Denny, P

AU - Brown, S

AU - Jones, H B

AU - Little, S

AU - Booth, G C

AU - McPheat, W L

PY - 2001/1

Y1 - 2001/1

N2 - From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.

AB - From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.

KW - Animals

KW - Bacteremia

KW - Genetic Predisposition to Disease

KW - H-2 Antigens

KW - Lung

KW - Mice

KW - Mice, Inbred Strains

KW - Neutrophils

KW - Pneumococcal Infections

KW - Species Specificity

U2 - 10.1128/IAI.69.1.426-434.2001

DO - 10.1128/IAI.69.1.426-434.2001

M3 - Article

C2 - 11119534

SN - 0019-9567

VL - 69

SP - 426

EP - 434

JO - Infection and Immunity

JF - Infection and Immunity

IS - 1

ER -

Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains

Abstract

Keywords

Access to Document

Fingerprint

Cite this