Role of dual specificity phosphatases in biological responses to glucocorticoids

Andrew R. Clark, Joana R.S. Martins, Carmen R. Tchen

Research output: Contribution to journalShort surveypeer-review

64 Citations (Scopus)

Abstract

The powerful anti-inflammatory effects of glucocorticoids (GCs) have been known for more than sixty years, but their molecular mechanisms are still incompletely understood and hotly debated. The GC receptor (GR) was cloned in 1985 and shown to be a transcription factor. Initially, the anti-inflammatory actions of GCs were explained in terms of genes that were up-regulated by the receptor. However, none of these putative mediators seemed able to account for the spectrum of anti-inflammatory responses to GCs. The discovery of a negative regulatory function of GR then shifted the focus away from GC-induced genes as anti-inflammatory mediators. In recent years, attention has begun to move back toward the idea that the antiinflammatory response to GCs is partially dependent on the positive regulation of gene expression by GR.

Original languageEnglish
Pages (from-to)25765-25769
Number of pages5
JournalJournal of Biological Chemistry
Volume283
Issue number38
DOIs
Publication statusPublished - 19 Sep 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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