Abstract
Dendritic cells (DCs) are a heterogeneous population. Murine DCs consist of conventional DCs (cDCs) and plasmacytoid DCs (pDCs). In human, the analogous populations are myeloid DCs (mDCs) and pDCs. Though distinct in phenotypes and functions, studies have shown that these DC subsets may interact or ‘crosstalk’ during immune responses. For example, cDCs may facilitate pDC maturation, while pDCs may enhance antigen presentation of cDCs in certain pathogenic conditions or even take on a cDC phenotype themselves. The role of DCs in non-infectious uveitis has been studied primarily in the experimental autoimmune uveitis mouse model and to a more limited extent in patients. Recent evidence shows that the number, phenotype and function of DC subsets are altered in this disease. We provide an overview of selected recent developments of pDCs and cDCs/mDCs, with special attention to their interaction and the dual roles of DC subsets in non-infectious uveitis.
| Original language | English |
|---|---|
| Journal | Survey Ophthalmol |
| Early online date | 27 Jan 2015 |
| DOIs | |
| Publication status | E-pub ahead of print - 27 Jan 2015 |
Access to Document
- Chen_et_al_Role_dendritic_cell_subsets_Survey_Ophthalmology_2015
NOTICE: this is the author’s version of a work that was accepted for publication in Survey of Ophthalmology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Survey of Ophthalmology, DOI: 10.1016/j.survophthal.2015.01.003. Eligibility for repository checked March 2015