Role of B-cell receptors for B-cell development and antigen-induced differentiation

Juan Carlos Yam-Puc; Lingling Zhang; Yang Zhang; Kai Michael Toellner

doi:10.12688/f1000research.13567.1

Role of B-cell receptors for B-cell development and antigen-induced differentiation

Juan Carlos Yam-Puc^*, Lingling Zhang, Yang Zhang, Kai Michael Toellner

^*Corresponding author for this work

Immunology and Immunotherapy

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

273 Downloads (Pure)

Abstract

B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.

Original language	English
Article number	429
Journal	F1000Research
Volume	7
DOIs	https://doi.org/10.12688/f1000research.13567.1
Publication status	Published - 6 Apr 2018

Keywords

B cell development
B cell differentiation
B cell receptor

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
Medicine (miscellaneous)

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10.12688/f1000research.13567.1Licence: Creative Commons: Attribution (CC BY)

Yam-Puc_et_al_Role_of_B-cell_receptors_F1000Research_2018
Published in F1000Research on 06/04/2018 DOI: 10.12688/f1000research.13567.1
Final published version, 1.43 MBLicence: Creative Commons: Attribution (CC BY)

https://f1000research.com/articles/7-429/v1Licence: Creative Commons: Attribution (CC BY)

Cite this

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abstract = "B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.",

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AU - Yam-Puc, Juan Carlos

AU - Zhang, Lingling

AU - Zhang, Yang

AU - Toellner, Kai Michael

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Y1 - 2018/4/6

N2 - B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.

AB - B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.

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KW - B cell differentiation

KW - B cell receptor

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JO - F1000Research

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ER -

Role of B-cell receptors for B-cell development and antigen-induced differentiation

Abstract

Keywords

ASJC Scopus subject areas

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