Role of apoptosis and cytokines in influenza virus morbidity

EWA Brydon, SJ Morris, Clive Sweet

Research output: Contribution to journalReview article

112 Citations (Scopus)


Influenza virus is a major human pathogen that causes epidemics and pandemics with increased morbidity and, especially in the elderly and those with pre-existing medical conditions, increased mortality. Influenza is characterised by respiratory symptoms and constitutional symptoms. Whilst knowledge of the mechanisms underlying host and tissue specificity has advanced considerably of late we still know relatively little about other aspects of influenza virus virulence. In this review, we will explore what is known about the role of apoptosis in respiratory epithelial cell damage and the role of cytokines in inflammation and constitutional symptoms with particular emphasis on the link between apoptosis, inflammation, fever and cytokine production.
Original languageEnglish
Pages (from-to)837-850
Number of pages14
JournalFEMS Microbiology Reviews
Issue number4
Publication statusPublished - 1 Sept 2005


  • cytokines
  • apoptosis
  • influenza virus
  • constitutional symptoms
  • fever
  • respiratory symptoms


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