Role of AMP-activated protein kinase in the regulation of gene transcription

I Leclerc, B Viollet, G da Silva Xavier, A Kahn, G A Rutter

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.

Original languageEnglish
Pages (from-to)307-11
Number of pages5
JournalBiochemical Society Transactions
Issue number2
Publication statusPublished - Apr 2002


  • AMP-Activated Protein Kinases
  • Animals
  • Enzyme Activation
  • Gene Expression Regulation
  • Humans
  • Islets of Langerhans/metabolism
  • Liver/metabolism
  • Multienzyme Complexes/genetics
  • Muscle, Skeletal/metabolism
  • Protein-Serine-Threonine Kinases/genetics
  • Saccharomyces cerevisiae/genetics
  • Signal Transduction
  • Transcription, Genetic


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