Role of AMP-activated protein kinase in the regulation of gene transcription

I Leclerc; B Viollet; G da Silva Xavier; A Kahn; G A Rutter

doi:10.1042/bst0300307

Role of AMP-activated protein kinase in the regulation of gene transcription

I Leclerc, B Viollet, G da Silva Xavier, A Kahn, G A Rutter

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.

Original language	English
Pages (from-to)	307-11
Number of pages	5
Journal	Biochemical Society Transactions
Volume	30
Issue number	2
DOIs	https://doi.org/10.1042/bst0300307
Publication status	Published - Apr 2002

Keywords

AMP-Activated Protein Kinases
Animals
Enzyme Activation
Gene Expression Regulation
Humans
Islets of Langerhans/metabolism
Liver/metabolism
Multienzyme Complexes/genetics
Muscle, Skeletal/metabolism
Protein-Serine-Threonine Kinases/genetics
Saccharomyces cerevisiae/genetics
Signal Transduction
Transcription, Genetic

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title = "Role of AMP-activated protein kinase in the regulation of gene transcription",

abstract = "AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.",

keywords = "AMP-Activated Protein Kinases, Animals, Enzyme Activation, Gene Expression Regulation, Humans, Islets of Langerhans/metabolism, Liver/metabolism, Multienzyme Complexes/genetics, Muscle, Skeletal/metabolism, Protein-Serine-Threonine Kinases/genetics, Saccharomyces cerevisiae/genetics, Signal Transduction, Transcription, Genetic",

author = "I Leclerc and B Viollet and {da Silva Xavier}, G and A Kahn and Rutter, {G A}",

year = "2002",

month = apr,

doi = "10.1042/bst0300307",

language = "English",

volume = "30",

pages = "307--11",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press",

number = "2",

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TY - JOUR

T1 - Role of AMP-activated protein kinase in the regulation of gene transcription

AU - Leclerc, I

AU - Viollet, B

AU - da Silva Xavier, G

AU - Kahn, A

AU - Rutter, G A

PY - 2002/4

Y1 - 2002/4

N2 - AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.

AB - AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.

KW - AMP-Activated Protein Kinases

KW - Animals

KW - Enzyme Activation

KW - Gene Expression Regulation

KW - Humans

KW - Islets of Langerhans/metabolism

KW - Liver/metabolism

KW - Multienzyme Complexes/genetics

KW - Muscle, Skeletal/metabolism

KW - Protein-Serine-Threonine Kinases/genetics

KW - Saccharomyces cerevisiae/genetics

KW - Signal Transduction

KW - Transcription, Genetic

U2 - 10.1042/bst0300307

DO - 10.1042/bst0300307

M3 - Review article

C2 - 12023870

SN - 0300-5127

VL - 30

SP - 307

EP - 311

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 2

ER -

Role of AMP-activated protein kinase in the regulation of gene transcription

Abstract

Keywords

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