Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years

Helen Parry; Paul Moss; Grace Uwenedi; Thomas Roberts; Panagiota Sylla; Jonathan Cook; Ahmed Elzaidi; May Lau; Tamsin Drury; Alexander Bray; Soumyajit Mallick; Katie Spencer; Christopher Bentley; Graham Mcilroy; Sam Scott; Nicola Logan; Jianmin Zuo; Brian Willett; Paul Moss

doi:10.1016/j.jinf.2023.08.014

Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years

Helen Parry
, Paul Moss
, Grace Uwenedi
, Thomas Roberts
, Panagiota Sylla
, Jonathan Cook
, Ahmed Elzaidi
, May Lau
, Tamsin Drury
, Alexander Bray
, Soumyajit Mallick
, Katie Spencer
, Christopher Bentley
, Graham Mcilroy
, Sam Scott
, Nicola Logan
, Jianmin Zuo
, Brian Willett
, Paul Moss^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

Original language	English
Journal	Journal of Infection
Early online date	1 Sept 2023
DOIs	https://doi.org/10.1016/j.jinf.2023.08.014
Publication status	E-pub ahead of print - 1 Sept 2023

Bibliographical note

Acknowledgments:
We thank Dr. Rory Meade, Dr. Philip Saunders, Dr. Rosie Laugharne, Dr. Tom Groves, Dr. Parjit Dhillon, Dr. Eleanor Brodie, and the patients and staff at Harborne Medical Practice, Lordswod Medical Group, Ridgacre House Surgery, Northumberland House Surgery, New Road Surgery, Lapal Medical Practice, and Wychbury Medical Group. We also thank Millie Manning, Danielle Sutherland for their help in recruitment. We are grateful for support from Rajinder Jeet, Shahada Rahman Joli, Anindita Roy and Ayaz Karim with phlebotomy services. This work was supported by the UK Coronavirus Immunology Consortium (UK-CIC) MR/V028448/1 awarded to PM, in addition to funding from DHSC/UKRI and the National Core Studies Immunity programme MC_PC_20031 and MC_PC_20060 awarded to PM. Additional support to B.W. from MRC (MC_UU_00034/6P).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.jinf.2023.08.014

COVID-19 Immunity - National Core Study (IMM-NCS)
Moss, P. (Principal Investigator)
Medical Research Council
1/10/20 → 31/03/21
Project: Research Councils
A UK underpinning platform to study immunology and immunopathology of COVID-19:The UK Coronavirus Immunology Consortium
Duggal, N. (Researcher), Zuo, J. (Researcher), Moss, P. (Principal Investigator), Long, H. (Researcher), Lord, J. (Researcher), Taylor, G. (Researcher) & Wraith, D. (Researcher)
Medical Research Council
20/08/20 → 31/10/22
Project: Research Councils

Cite this

Parry, H., Moss, P., Uwenedi, G., Roberts, T., Sylla, P., Cook, J., Elzaidi, A., Lau, M., Drury, T., Bray, A., Mallick, S., Spencer, K., Bentley, C., Mcilroy, G., Scott, S., Logan, N., Zuo, J., Willett, B., & Moss, P. (2023). Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years. Journal of Infection. Advance online publication. https://doi.org/10.1016/j.jinf.2023.08.014

@article{e223088f8683401cabace006202f70ef,

title = "Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years",

author = "Helen Parry and Paul Moss and Grace Uwenedi and Thomas Roberts and Panagiota Sylla and Jonathan Cook and Ahmed Elzaidi and May Lau and Tamsin Drury and Alexander Bray and Soumyajit Mallick and Katie Spencer and Christopher Bentley and Graham Mcilroy and Sam Scott and Nicola Logan and Jianmin Zuo and Brian Willett and Paul Moss",

note = "Acknowledgments: We thank Dr. Rory Meade, Dr. Philip Saunders, Dr. Rosie Laugharne, Dr. Tom Groves, Dr. Parjit Dhillon, Dr. Eleanor Brodie, and the patients and staff at Harborne Medical Practice, Lordswod Medical Group, Ridgacre House Surgery, Northumberland House Surgery, New Road Surgery, Lapal Medical Practice, and Wychbury Medical Group. We also thank Millie Manning, Danielle Sutherland for their help in recruitment. We are grateful for support from Rajinder Jeet, Shahada Rahman Joli, Anindita Roy and Ayaz Karim with phlebotomy services. This work was supported by the UK Coronavirus Immunology Consortium (UK-CIC) MR/V028448/1 awarded to PM, in addition to funding from DHSC/UKRI and the National Core Studies Immunity programme MC\_PC\_20031 and MC\_PC\_20060 awarded to PM. Additional support to B.W. from MRC (MC\_UU\_00034/6P).",

year = "2023",

month = sep,

day = "1",

doi = "10.1016/j.jinf.2023.08.014",

language = "English",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "Elsevier",

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Parry, H , Moss, P, Uwenedi, G, Roberts, T, Sylla, P, Cook, J, Elzaidi, A, Lau, M, Drury, T, Bray, A, Mallick, S, Spencer, K, Bentley, C, Mcilroy, G, Scott, S, Logan, N, Zuo, J, Willett, B & Moss, P 2023, 'Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years', Journal of Infection. https://doi.org/10.1016/j.jinf.2023.08.014

TY - JOUR

T1 - Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years

AU - Parry, Helen

AU - Moss, Paul

AU - Uwenedi, Grace

AU - Roberts, Thomas

AU - Sylla, Panagiota

AU - Cook, Jonathan

AU - Elzaidi, Ahmed

AU - Lau, May

AU - Drury, Tamsin

AU - Bray, Alexander

AU - Mallick, Soumyajit

AU - Spencer, Katie

AU - Bentley, Christopher

AU - Mcilroy, Graham

AU - Scott, Sam

AU - Logan, Nicola

AU - Zuo, Jianmin

AU - Willett, Brian

AU - Moss, Paul

N1 - Acknowledgments: We thank Dr. Rory Meade, Dr. Philip Saunders, Dr. Rosie Laugharne, Dr. Tom Groves, Dr. Parjit Dhillon, Dr. Eleanor Brodie, and the patients and staff at Harborne Medical Practice, Lordswod Medical Group, Ridgacre House Surgery, Northumberland House Surgery, New Road Surgery, Lapal Medical Practice, and Wychbury Medical Group. We also thank Millie Manning, Danielle Sutherland for their help in recruitment. We are grateful for support from Rajinder Jeet, Shahada Rahman Joli, Anindita Roy and Ayaz Karim with phlebotomy services. This work was supported by the UK Coronavirus Immunology Consortium (UK-CIC) MR/V028448/1 awarded to PM, in addition to funding from DHSC/UKRI and the National Core Studies Immunity programme MC_PC_20031 and MC_PC_20060 awarded to PM. Additional support to B.W. from MRC (MC_UU_00034/6P).

PY - 2023/9/1

Y1 - 2023/9/1

U2 - 10.1016/j.jinf.2023.08.014

DO - 10.1016/j.jinf.2023.08.014

M3 - Letter

C2 - 37660756

SN - 0163-4453

JO - Journal of Infection

JF - Journal of Infection

ER -

Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years

Bibliographical note

UN SDGs

Access to Document

Projects

COVID-19 Immunity - National Core Study (IMM-NCS)

A UK underpinning platform to study immunology and immunopathology of COVID-19:The UK Coronavirus Immunology Consortium

Cite this