Robust associations of four new chromosome regions from genome-wide analyses of type 1

JA Todd; NM Walker; JD Cooper; DJ Smyth; K Downes; V Plagnol; R Bailey; S Nejenstev; SF Field; F Payne; CE Lowe; JS Szeszko; JP Hafler; L Zeitels; JH Yang; A Vella; S Nutland; HE Stevens; H Schuilenburg; G Coleman; M Maisuria; W Meadows; LJ Smink; B Healy; OS Burren; AA Lam; NR Ovington; J Allen; E Adlem; HT Leung; C Wallace; JM Howson; C Guja; C Ionescu-Tirgoviste; A Genetics of type 1 diabeted in Finland; Matthew Simmonds; Joanne King; Stephen Gough; A Wellcome Trust Case Consortium; DB Dunger; LS Wicker; DG Clayton

doi:10.1038/ng2068

Robust associations of four new chromosome regions from genome-wide analyses of type 1

JA Todd, NM Walker, JD Cooper, DJ Smyth, K Downes, V Plagnol, R Bailey, S Nejenstev, SF Field, F Payne, CE Lowe, JS Szeszko, JP Hafler, L Zeitels, JH Yang, A Vella, S Nutland, HE Stevens, H Schuilenburg, G ColemanM Maisuria, W Meadows, LJ Smink, B Healy, OS Burren, AA Lam, NR Ovington, J Allen, E Adlem, HT Leung, C Wallace, JM Howson, C Guja, C Ionescu-Tirgoviste, A Genetics of type 1 diabeted in Finland, Matthew Simmonds, Joanne King, Stephen Gough, A Wellcome Trust Case Consortium, DB Dunger, LS Wicker, DG Clayton

Birmingham Medical School

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Abstract

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P <5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up)

Original language	English
Pages (from-to)	857-64
Number of pages	8
Journal	Nature Genetics
Volume	39
Issue number	7
DOIs	https://doi.org/10.1038/ng2068
Publication status	Published - 6 Jun 2007

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Todd, JA., Walker, NM., Cooper, JD., Smyth, DJ., Downes, K., Plagnol, V., Bailey, R., Nejenstev, S., Field, SF., Payne, F., Lowe, CE., Szeszko, JS., Hafler, JP., Zeitels, L., Yang, JH., Vella, A., Nutland, S., Stevens, HE., Schuilenburg, H., ... Clayton, DG. (2007). Robust associations of four new chromosome regions from genome-wide analyses of type 1. Nature Genetics, 39(7), 857-64. https://doi.org/10.1038/ng2068

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title = "Robust associations of four new chromosome regions from genome-wide analyses of type 1",

abstract = "The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P <5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) ",

author = "JA Todd and NM Walker and JD Cooper and DJ Smyth and K Downes and V Plagnol and R Bailey and S Nejenstev and SF Field and F Payne and CE Lowe and JS Szeszko and JP Hafler and L Zeitels and JH Yang and A Vella and S Nutland and HE Stevens and H Schuilenburg and G Coleman and M Maisuria and W Meadows and LJ Smink and B Healy and OS Burren and AA Lam and NR Ovington and J Allen and E Adlem and HT Leung and C Wallace and JM Howson and C Guja and C Ionescu-Tirgoviste and {Genetics of type 1 diabeted in Finland}, A and Matthew Simmonds and Joanne King and Stephen Gough and {Wellcome Trust Case Consortium}, A and DB Dunger and LS Wicker and DG Clayton",

year = "2007",

month = jun,

day = "6",

doi = "10.1038/ng2068",

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Todd, JA, Walker, NM, Cooper, JD, Smyth, DJ, Downes, K, Plagnol, V, Bailey, R, Nejenstev, S, Field, SF, Payne, F, Lowe, CE, Szeszko, JS, Hafler, JP, Zeitels, L, Yang, JH, Vella, A, Nutland, S, Stevens, HE, Schuilenburg, H, Coleman, G, Maisuria, M, Meadows, W, Smink, LJ, Healy, B, Burren, OS, Lam, AA, Ovington, NR, Allen, J, Adlem, E, Leung, HT, Wallace, C, Howson, JM, Guja, C, Ionescu-Tirgoviste, C, Genetics of type 1 diabeted in Finland, A, Simmonds, M, King, J, Gough, S, Wellcome Trust Case Consortium, A, Dunger, DB, Wicker, LS & Clayton, DG 2007, 'Robust associations of four new chromosome regions from genome-wide analyses of type 1', Nature Genetics, vol. 39, no. 7, pp. 857-64. https://doi.org/10.1038/ng2068

TY - JOUR

T1 - Robust associations of four new chromosome regions from genome-wide analyses of type 1

AU - Todd, JA

AU - Walker, NM

AU - Cooper, JD

AU - Smyth, DJ

AU - Downes, K

AU - Plagnol, V

AU - Bailey, R

AU - Nejenstev, S

AU - Field, SF

AU - Payne, F

AU - Lowe, CE

AU - Szeszko, JS

AU - Hafler, JP

AU - Zeitels, L

AU - Yang, JH

AU - Vella, A

AU - Nutland, S

AU - Stevens, HE

AU - Schuilenburg, H

AU - Coleman, G

AU - Maisuria, M

AU - Meadows, W

AU - Smink, LJ

AU - Healy, B

AU - Burren, OS

AU - Lam, AA

AU - Ovington, NR

AU - Allen, J

AU - Adlem, E

AU - Leung, HT

AU - Wallace, C

AU - Howson, JM

AU - Guja, C

AU - Ionescu-Tirgoviste, C

AU - Genetics of type 1 diabeted in Finland, A

AU - Simmonds, Matthew

AU - King, Joanne

AU - Gough, Stephen

AU - Wellcome Trust Case Consortium, A

AU - Dunger, DB

AU - Wicker, LS

AU - Clayton, DG

PY - 2007/6/6

Y1 - 2007/6/6

N2 - The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P <5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up)

AB - The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P <5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up)

U2 - 10.1038/ng2068

DO - 10.1038/ng2068

M3 - Article

C2 - 17554260

SN - 1546-1718

VL - 39

SP - 857

EP - 864

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

Robust associations of four new chromosome regions from genome-wide analyses of type 1

Abstract

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