RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance

Abigail L Colclough; Ilyas Alav; Emily E Whittle; Hannah L Pugh; Elizabeth M Darby; Simon W Legood; Helen E McNeil; Jessica MA Blair

doi:10.2217/fmb-2019-0235

RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance

Abigail L Colclough, Ilyas Alav, Emily E Whittle, Hannah L Pugh, Elizabeth M Darby, Simon W Legood, Helen E McNeil, Jessica MA Blair

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

Abstract

Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance. There is also emerging evidence that many other mechanisms of antibiotic resistance rely on the intrinsic resistance conferred by RND efflux. In addition to their role in antibiotic resistance, new information has become available about the natural role of RND pumps including their established role in virulence of many Gram-negative organisms. This review also discusses the recent advances in understanding the regulation and structure of RND efflux pumps.

Original language	English
Journal	Future Microbiology
Volume	15
Issue number	2
DOIs	https://doi.org/10.2217/fmb-2019-0235
Publication status	Published - Jan 2020

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title = "RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance",

abstract = "Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance. There is also emerging evidence that many other mechanisms of antibiotic resistance rely on the intrinsic resistance conferred by RND efflux. In addition to their role in antibiotic resistance, new information has become available about the natural role of RND pumps including their established role in virulence of many Gram-negative organisms. This review also discusses the recent advances in understanding the regulation and structure of RND efflux pumps.",

author = "Colclough, {Abigail L} and Ilyas Alav and Whittle, {Emily E} and Pugh, {Hannah L} and Darby, {Elizabeth M} and Legood, {Simon W} and McNeil, {Helen E} and Blair, {Jessica MA}",

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AU - Colclough, Abigail L

AU - Alav, Ilyas

AU - Whittle, Emily E

AU - Pugh, Hannah L

AU - Darby, Elizabeth M

AU - Legood, Simon W

AU - McNeil, Helen E

AU - Blair, Jessica MA

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Y1 - 2020/1

N2 - Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance. There is also emerging evidence that many other mechanisms of antibiotic resistance rely on the intrinsic resistance conferred by RND efflux. In addition to their role in antibiotic resistance, new information has become available about the natural role of RND pumps including their established role in virulence of many Gram-negative organisms. This review also discusses the recent advances in understanding the regulation and structure of RND efflux pumps.

AB - Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance. There is also emerging evidence that many other mechanisms of antibiotic resistance rely on the intrinsic resistance conferred by RND efflux. In addition to their role in antibiotic resistance, new information has become available about the natural role of RND pumps including their established role in virulence of many Gram-negative organisms. This review also discusses the recent advances in understanding the regulation and structure of RND efflux pumps.

UR - https://doi.org/10.2217/fmb-2019-0235

U2 - 10.2217/fmb-2019-0235

DO - 10.2217/fmb-2019-0235

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VL - 15

JO - Future Microbiology

JF - Future Microbiology

IS - 2

ER -

RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance

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