Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study

Alessandro Parente; Sivesh K Kamarajah; Joseph P. Thompson; Charlotte Crook; Sebastian Aspinall; Ross Melvin; Michael J Stechman; Helen Perry; Sabapathy P Balasubramanian; Arslan Pannu; Fausto F Palazzo; Klaas Van Den Heede; Fiona Eatock; Hannah Anderson; Helen Doran; Kelvin Wang; Johnathan Hubbard; Abdulaziz Aldrees; Susannah L Shore; Clare Fung; Alison Waghorn; John Ayuk; Davinia Bennett; Robert P Sutcliffe

doi:10.1093/bjsopen/zrad090

Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study

Alessandro Parente^*
, Sivesh K Kamarajah
, Joseph P. Thompson
, Charlotte Crook
, Sebastian Aspinall
, Ross Melvin
, Michael J Stechman
, Helen Perry
, Sabapathy P Balasubramanian
, Arslan Pannu
, Fausto F Palazzo
, Klaas Van Den Heede
, Fiona Eatock
, Hannah Anderson
, Helen Doran
, Kelvin Wang
, Johnathan Hubbard
, Abdulaziz Aldrees
, Susannah L Shore
, Clare Fung

Alison Waghorn, John Ayuk, Davinia Bennett, Robert P Sutcliffe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: To determine the incidence and risk factors for postoperative complications and prolonged hospital stay after adrenalectomy for phaeochromocytoma. Methods: Demographics, perioperative outcomes and complications were evaluated for consecutive patients who underwent adrenalectomy for phaeochromocytoma from 2012 to 2020 in nine high-volume UK centres. Odds ratios were calculated using multivariable models. The primary outcome was postoperative complications according to the Clavien–Dindo classification and secondary outcome was duration of hospital stay. Results: Data were available for 406 patients (female n = 221, 54.4 per cent). Two patients (0.5 per cent) had perioperative death, whilst 148 complications were recorded in 109 (26.8 per cent) patients. On adjusted analysis, the age-adjusted Charlson Co-morbidity Index ≥3 (OR 8.09, 95 per cent c.i. 2.31 to 29.63, P = 0.001), laparoscopic converted to open (OR 10.34, 95 per cent c.i. 3.24 to 36.23, P

Original language	English
Article number	zrad090
Number of pages	8
Journal	BJS Open
Volume	7
Issue number	5
DOIs	https://doi.org/10.1093/bjsopen/zrad090
Publication status	Published - 27 Sept 2023

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Parente, A., Kamarajah, S. K., Thompson, J. P., Crook, C., Aspinall, S., Melvin, R., Stechman, M. J., Perry, H., Balasubramanian, S. P., Pannu, A., Palazzo, F. F., Van Den Heede, K., Eatock, F., Anderson, H., Doran, H., Wang, K., Hubbard, J., Aldrees, A., Shore, S. L., ... Sutcliffe, R. P. (2023). Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study. BJS Open, 7(5), Article zrad090. https://doi.org/10.1093/bjsopen/zrad090

@article{c2f7321a09ff4ecd8099d55e49f70d1f,

title = "Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study",

abstract = "Background: To determine the incidence and risk factors for postoperative complications and prolonged hospital stay after adrenalectomy for phaeochromocytoma. Methods: Demographics, perioperative outcomes and complications were evaluated for consecutive patients who underwent adrenalectomy for phaeochromocytoma from 2012 to 2020 in nine high-volume UK centres. Odds ratios were calculated using multivariable models. The primary outcome was postoperative complications according to the Clavien–Dindo classification and secondary outcome was duration of hospital stay. Results: Data were available for 406 patients (female n = 221, 54.4 per cent). Two patients (0.5 per cent) had perioperative death, whilst 148 complications were recorded in 109 (26.8 per cent) patients. On adjusted analysis, the age-adjusted Charlson Co-morbidity Index ≥3 (OR 8.09, 95 per cent c.i. 2.31 to 29.63, P = 0.001), laparoscopic converted to open (OR 10.34, 95 per cent c.i. 3.24 to 36.23, P",

author = "Alessandro Parente and Kamarajah, \{Sivesh K\} and Thompson, \{Joseph P.\} and Charlotte Crook and Sebastian Aspinall and Ross Melvin and Stechman, \{Michael J\} and Helen Perry and Balasubramanian, \{Sabapathy P\} and Arslan Pannu and Palazzo, \{Fausto F\} and \{Van Den Heede\}, Klaas and Fiona Eatock and Hannah Anderson and Helen Doran and Kelvin Wang and Johnathan Hubbard and Abdulaziz Aldrees and Shore, \{Susannah L\} and Clare Fung and Alison Waghorn and John Ayuk and Davinia Bennett and Sutcliffe, \{Robert P\}",

year = "2023",

month = sep,

day = "27",

doi = "10.1093/bjsopen/zrad090",

language = "English",

volume = "7",

journal = "BJS Open",

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Parente, A, Kamarajah, SK, Thompson, JP, Crook, C, Aspinall, S, Melvin, R, Stechman, MJ, Perry, H, Balasubramanian, SP, Pannu, A, Palazzo, FF, Van Den Heede, K, Eatock, F, Anderson, H, Doran, H, Wang, K, Hubbard, J, Aldrees, A, Shore, SL, Fung, C, Waghorn, A, Ayuk, J, Bennett, D & Sutcliffe, RP 2023, 'Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study', BJS Open, vol. 7, no. 5, zrad090. https://doi.org/10.1093/bjsopen/zrad090

TY - JOUR

T1 - Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study

AU - Parente, Alessandro

AU - Kamarajah, Sivesh K

AU - Thompson, Joseph P.

AU - Crook, Charlotte

AU - Aspinall, Sebastian

AU - Melvin, Ross

AU - Stechman, Michael J

AU - Perry, Helen

AU - Balasubramanian, Sabapathy P

AU - Pannu, Arslan

AU - Palazzo, Fausto F

AU - Van Den Heede, Klaas

AU - Eatock, Fiona

AU - Anderson, Hannah

AU - Doran, Helen

AU - Wang, Kelvin

AU - Hubbard, Johnathan

AU - Aldrees, Abdulaziz

AU - Shore, Susannah L

AU - Fung, Clare

AU - Waghorn, Alison

AU - Ayuk, John

AU - Bennett, Davinia

AU - Sutcliffe, Robert P

PY - 2023/9/27

Y1 - 2023/9/27

N2 - Background: To determine the incidence and risk factors for postoperative complications and prolonged hospital stay after adrenalectomy for phaeochromocytoma. Methods: Demographics, perioperative outcomes and complications were evaluated for consecutive patients who underwent adrenalectomy for phaeochromocytoma from 2012 to 2020 in nine high-volume UK centres. Odds ratios were calculated using multivariable models. The primary outcome was postoperative complications according to the Clavien–Dindo classification and secondary outcome was duration of hospital stay. Results: Data were available for 406 patients (female n = 221, 54.4 per cent). Two patients (0.5 per cent) had perioperative death, whilst 148 complications were recorded in 109 (26.8 per cent) patients. On adjusted analysis, the age-adjusted Charlson Co-morbidity Index ≥3 (OR 8.09, 95 per cent c.i. 2.31 to 29.63, P = 0.001), laparoscopic converted to open (OR 10.34, 95 per cent c.i. 3.24 to 36.23, P

AB - Background: To determine the incidence and risk factors for postoperative complications and prolonged hospital stay after adrenalectomy for phaeochromocytoma. Methods: Demographics, perioperative outcomes and complications were evaluated for consecutive patients who underwent adrenalectomy for phaeochromocytoma from 2012 to 2020 in nine high-volume UK centres. Odds ratios were calculated using multivariable models. The primary outcome was postoperative complications according to the Clavien–Dindo classification and secondary outcome was duration of hospital stay. Results: Data were available for 406 patients (female n = 221, 54.4 per cent). Two patients (0.5 per cent) had perioperative death, whilst 148 complications were recorded in 109 (26.8 per cent) patients. On adjusted analysis, the age-adjusted Charlson Co-morbidity Index ≥3 (OR 8.09, 95 per cent c.i. 2.31 to 29.63, P = 0.001), laparoscopic converted to open (OR 10.34, 95 per cent c.i. 3.24 to 36.23, P

U2 - 10.1093/bjsopen/zrad090

DO - 10.1093/bjsopen/zrad090

M3 - Article

SN - 2474-9842

VL - 7

JO - BJS Open

JF - BJS Open

IS - 5

M1 - zrad090

ER -

Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study

Abstract

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