Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study

Alessandro Parente*, Sivesh K Kamarajah, Joseph P. Thompson, Charlotte Crook, Sebastian Aspinall, Ross Melvin, Michael J Stechman, Helen Perry, Sabapathy P Balasubramanian, Arslan Pannu, Fausto F Palazzo, Klaas Van Den Heede, Fiona Eatock, Hannah Anderson, Helen Doran, Kelvin Wang, Johnathan Hubbard, Abdulaziz Aldrees, Susannah L Shore, Clare FungAlison Waghorn, John Ayuk, Davinia Bennett, Robert P Sutcliffe

*Corresponding author for this work

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Abstract

Background: To determine the incidence and risk factors for postoperative complications and prolonged hospital stay after adrenalectomy for phaeochromocytoma. Methods: Demographics, perioperative outcomes and complications were evaluated for consecutive patients who underwent adrenalectomy for phaeochromocytoma from 2012 to 2020 in nine high-volume UK centres. Odds ratios were calculated using multivariable models. The primary outcome was postoperative complications according to the Clavien–­­Dindo classification and secondary outcome was duration of hospital stay. Results: Data were available for 406 patients (female n = 221, 54.4 per cent). Two patients (0.5 per cent) had perioperative death, whilst 148 complications were recorded in 109 (26.8 per cent) patients. On adjusted analysis, the age-adjusted Charlson Co-morbidity Index ≥3 (OR 8.09, 95 per cent c.i. 2.31 to 29.63, P = 0.001), laparoscopic converted to open (OR 10.34, 95 per cent c.i. 3.24 to 36.23, P
Original languageEnglish
Article numberzrad090
Number of pages8
JournalBJS Open
Volume7
Issue number5
DOIs
Publication statusPublished - 27 Sept 2023

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