Rho GTPase signalling pathways in the morphological changes associated with apoptosis

M L Coleman; M F Olson

doi:10.1038/sj/cdd/4400987

Rho GTPase signalling pathways in the morphological changes associated with apoptosis

M L Coleman, M F Olson

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

183 Citations (Scopus)

Abstract

The killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture. In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.

Original language	English
Pages (from-to)	493-504
Number of pages	12
Journal	Cell Death & Differentiation
Volume	9
Issue number	5
DOIs	https://doi.org/10.1038/sj/cdd/4400987
Publication status	Published - May 2002

Keywords

Actin Cytoskeleton
Animals
Apoptosis
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Caspases
Humans
Mammals
Membrane Proteins
Phagocytosis
Signal Transduction
rho GTP-Binding Proteins

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abstract = "The killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture. In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.",

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AU - Olson, M F

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AB - The killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture. In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.

KW - Actin Cytoskeleton

KW - Animals

KW - Apoptosis

KW - Caenorhabditis elegans

KW - Caenorhabditis elegans Proteins

KW - Caspases

KW - Humans

KW - Mammals

KW - Membrane Proteins

KW - Phagocytosis

KW - Signal Transduction

KW - rho GTP-Binding Proteins

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DO - 10.1038/sj/cdd/4400987

M3 - Article

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SN - 1350-9047

VL - 9

SP - 493

EP - 504

JO - Cell Death & Differentiation

JF - Cell Death & Differentiation

IS - 5

ER -

Rho GTPase signalling pathways in the morphological changes associated with apoptosis

Abstract

Keywords

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