Review on marine sponge alkaloid, aaptamine: a potential antibacterial and anticancer drug

Vinita Manimaran Nadar, Selvambigai Manivannan, Rajasekar Chinnaiyan, Muthusamy Govarthanan, Kumar Ponnuchamy

Research output: Contribution to journalReview articlepeer-review

Abstract

In recent years, biological macromolecules have piqued the interest of researchers owing to their vast variety of biological uses. As a result, the marine sponge is a multicellular heterotrophic parazoan with chemicals for defence against predator assaults, biofouling and microbial diseases. These priceless molecules are known as secondary metabolites, and they are essential for survival in a highly competitive environment. So far, over 5,000 marine natural compounds have been extracted from marine sponges, making them an excellent option for drug formulation. One among them is, aaptamine, a marine alkaloid with a benzo[de][1,6]-napthyridine framework extensively distributed in marine sponges. Due to this reason, aaptamine has been intensively researched for various biological purposes, including cancer and protease inhibition, offering fresh insights into novel treatments. Keeping this in mind, we reviewed the biological significance of the marine sponge alkaloid aaptamine.

Original languageEnglish
JournalChem Biol Drug Design
Early online date31 Jul 2021
DOIs
Publication statusE-pub ahead of print - 31 Jul 2021

Keywords

  • aaptamine
  • alkaloid
  • anticancer
  • antiviral agents
  • marine sponge

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