Abstract
The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 +/- 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 +/- 8.9 pg ml(-1) (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 +/- 3.9 ng ml(-1) (9.6%) and 37.7 +/- 55.6 ng ml(-1) (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
| Original language | English |
|---|---|
| Pages (from-to) | 247-51 |
| Number of pages | 5 |
| Journal | Cell Stress and Chaperones |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 |
Keywords
- Adult
- Blood Volume
- Cytokine Receptor gp130
- Exercise Test
- Fatigue
- Heart Rate
- Humans
- Interleukin-6
- Lactates
- Male
- Middle Aged
- Motor Activity
- Oxygen Consumption
- Physical Exertion
- Receptors, Interleukin-6
- Solubility