Respiratory virus infections in adult T cell-depleted transplant recipients: the role of cellular immunity.

Suparno Chakrabarti, KE Collingham, T Marshall, K Holder, T Gentle, G Hale, Christopher Fegan, Donald Milligan

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

BACKGROUND: Little is known about the role of cellular immunity in respiratory virus infections after bone marrow transplantation. METHODS: Forty allograft recipients T-cell depleted with Campath antibodies were evaluated for respiratory virus infections in an active surveillance program with early initiation of antiviral therapy. RESULTS: Eighteen episodes of respiratory virus infection were detected in nine patients (22%) at a median of 95 days, with lower respiratory involvement in 44%. Fourteen episodes were treated with antiviral therapy for 7 to 46 days, with 11% mortality. Respiratory virus infections were more common in patients receiving Campath 100 mg in vivo, but delayed CD4+ recovery was the most significant risk factor. CONCLUSIONS: Respiratory virus infections are common and often recurrent in patients with severe CD4+ T lymphopenia. However, the mortality was low, which may have been due to early institution of antiviral treatment or reduced inflammatory damage to the lungs due to severe lymphopenia.
Original languageEnglish
Pages (from-to)1460-3
Number of pages4
JournalTransplantation
Volume72
Issue number8
Publication statusPublished - 27 Oct 2001

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