TY - JOUR
T1 - Resistin - the link between central obesity and type 2 diabetes?
AU - McTernan, Philip
AU - McTernan, Claire
AU - Harte, Alison
AU - Barnett, Anthony
AU - Kumar, Sudhesh
PY - 2002/1/5
Y1 - 2002/1/5
N2 - Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
AB - Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
UR - http://www.scopus.com/inward/record.url?scp=0037022005&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(02)07281-1
DO - 10.1016/S0140-6736(02)07281-1
M3 - Article
C2 - 11809189
SN - 1474-547X
VL - 359
SP - 46
EP - 47
JO - Lancet
JF - Lancet
IS - 9300
ER -