Resistin - the link between central obesity and type 2 diabetes?

Philip McTernan, Claire McTernan, Alison Harte, Anthony Barnett, Sudhesh Kumar

Research output: Contribution to journalArticle

334 Citations (Scopus)


Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
Original languageEnglish
Pages (from-to)46-47
Number of pages2
Issue number9300
Publication statusPublished - 5 Jan 2002


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