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Abstract
Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.
Original language | English |
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Pages (from-to) | 281-289 |
Number of pages | 9 |
Journal | Nature Reviews Microbiology |
Volume | 8 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2010 |
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Dive into the research topics of 'Resistance to and synthesis of the antibiotic mupirocin'. Together they form a unique fingerprint.Projects
- 1 Finished
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Biosynthesis of polyketide antibiotic mupirocin by Pseudomonas fluorescens
Biotechnology & Biological Sciences Research Council
1/06/07 → 30/01/11
Project: Research Councils