Research prioritization of interventions for the primary prevention of preterm birth: An international survey

John Allotey, Anca Matei, Shahid Husain, Sian Newton, Julie Dodds, Anthony B Armson, Khalid S Khan, Joshua P Vogel

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To identify research priorities of interventions for the primary prevention of preterm birth (PTB), by conducting an international stakeholder survey.

STUDY DESIGN: A prospective cross-sectional online survey was conducted in November 2016. Fifteen interventions to prevent spontaneous PTB were identified and ranked by stakeholders (n = 159) in the field of maternal and perinatal health research, using nine equally weighted criteria. Medians and interquartile ranges (IQRs) were calculated and the interventions ranked accordingly.

RESULTS: Respondents to the survey were from 46 different countries, mostly from low and middle-income countries (62%, 99/159) and were mainly clinicians (80%, 127/159). Of the fifteen interventions ranked, the following five were identified as research priorities in the primary prevention of PTB: dietary counselling and nutritional education, risk scoring, vitamin D supplementation, exercise and antioxidant supplementation.

CONCLUSION: We have identified research priorities of interventions to prevent spontaneous PTB through a global stakeholder survey. The interventions prioritized in this exercise can be used by researchers, grant funding bodies and research-policy decision makers to inform calls on future clinical trials or individual patient data meta-analyses on the primary prevention of PTB.

Original languageEnglish
Pages (from-to)240-248
Number of pages9
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Publication statusPublished - May 2019

Bibliographical note

Copyright © 2019 Elsevier B.V. All rights reserved.


  • Cross-Sectional Studies
  • Humans
  • Premature Birth/prevention & control
  • Primary Prevention
  • Research
  • Surveys and Questionnaires


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