Reproducibility of the transvaginal sonographic assessment of bladder wall thickness

Suneetha Rachaneni*, Lee Middleton, Anuradha Sajja, Moji Balogun, Jane Daniels, Pallavi Latthe, Jonathan Deeks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective To assess whether transvaginal sonographic measurements of bladder wall thickness (BWT) have adequate reproducibility to detect differences in BWT potentially indicative of detrusor overactivity in women with overactive bladder. Study design Three reproducibility studies were undertaken to assess (A) total measurement error, (B) intra-observer variability and (C) inter-observer measurement in the interpretation of scans. Women recruited to the Bladder Ultrasound Study underwent a transvaginal ultrasound scan to obtain a measurement of BWT. When a second observer was available, women who agreed to have two transvaginal scans by different operators were recruited into study A. For study B the first observer reassessed a sample of the recorded images at a later date whilst for study C, a random selection of BWT images were read by a second assessor. Analytical variability, percentage of variability attributable to measurement error, within-person variation and the smallest real difference detectable were estimated. Results One hundred and twenty-one women took part: 27 had repeat scans, 37 had scans re-read by the same observer, and 57 had scans read by two observers. In study A, 39% of the total variability in measurements was explained by measurement error (the remainder to within person change); the standard deviation (SD) of measurement error was 0.76 mm and the smallest detectable clinical difference was 2.1 mm. The SD of measurement error from scan interpretation was 0.42 mm within observers (study B) and 0.35 mm between observers (study C). Conclusion The high levels of measurement error for a small measurement of BWT means it is unlikely Transvaginal ultrasound measurements have insufficient reliability and reproducibility to be an accurate diagnostic test.

Original languageEnglish
Pages (from-to)88-95
Number of pages8
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Early online date22 Nov 2017
Publication statusPublished - 1 Jan 2018


  • Analytical variability
  • Bladder wall thickness
  • Interobserver
  • Intraobserver
  • Overactive bladder
  • Transvaginal ulstrasound

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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