Renal Denervation in Patients With Uncontrolled Hypertension and Confirmed Adherence to Antihypertensive Medications

Mohammed Awais Hameed, Mark Pucci, Una Martin, Richard Watkin, Sagar Doshi, Jonathan Freedman, Peter Riley, Jonathan Townend, Paul Crowe, Graham Lipkin, Indranil Dasgupta

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Renal denervation (RDN) has emerged as a potential device-based treatment for resistant hypertension. The authors present their experience of the use of catheter-based RDN as part of routine clinical care in two specialist hypertension clinics. Thirty-four patients with uncontrolled hypertension underwent RDN. All patients had ambulatory blood pressure (BP) monitoring and directly observed medication administration prior to the procedure to exclude white-coat hypertension and nonadherence, respectively. Overall, there was a significant change in clinic systolic BP of -15.1 mm Hg (95% confidence interval, -23.4 to -6.8; P=.001) and clinic diastolic BP of -6.2 mm Hg (95% confidence interval, -11.5 to -0.9; P=.02) 6 months postprocedure, and a nonsignificant change in daytime ambulatory BP of -5.4/-2.9 mm Hg. Eighteen patients (51.4%) showed a significant reduction in their clinic systolic BP (≥10 mm Hg) and 16 (47%) had a significant reduction in their daytime ambulatory systolic BP (≥5 mm Hg) at 6 months.

Original languageEnglish
JournalJournal of Clinical Hypertension
Early online date5 Oct 2015
DOIs
Publication statusE-pub ahead of print - 5 Oct 2015

Fingerprint

Dive into the research topics of 'Renal Denervation in Patients With Uncontrolled Hypertension and Confirmed Adherence to Antihypertensive Medications'. Together they form a unique fingerprint.

Cite this