Remotely Actuated Magnetic Nanocarpets for Bone Tissue Engineering: Non‐Invasive Modulation of Mechanosensitive Ion Channels for Enhanced Osteogenesis

Afeesh Rajan Unnithan, Arathyram Ramachandra Kurup Sasikala, Bishnu Kumar Shrestha, Alex Lincoln, Thomas Thomson, Alicia J. El Haj

Research output: Contribution to journalArticlepeer-review

Abstract

Non-invasive approaches using remotely controllable nanomaterials have demonstrated their potential ability to enhance treatment efficacy in regenerative medicine and tissue repair. Although magnetic nanoparticles (MNPs) have been used for multiple healthcare applications where their remote control properties can show significant advances, enhanced surface functional groups, and electrical properties would expand their capabilities. To address this, in this study, MNPs incorporated Graphene Oxide (GO) based nanocomposites (GOMNPs) are developed and functionalized with TREK1 and Piezo1 antibodies to specifically target the respective mechanosensitive ion channels. Magnetic ion channel activation (MICA) technology is used to remotely activate MG63 osteoblast-like cells tagged with these functionalized GOMNPs. Remote activation of mechanotransduction pathways shows significant upregulation in osteogenic gene expression as well as enhanced alkaline phosphate activity and calcium mineralization with enhanced bone formation. The development of a GOMNP composite has extensive applicability for future clinical translation.
Original languageEnglish
Article number2201311
JournalAdvanced Functional Materials
Early online date9 Jul 2022
DOIs
Publication statusE-pub ahead of print - 9 Jul 2022

Keywords

  • magnetic nanoparticles
  • mechanosensitive ion channels
  • mechanotransduction
  • osteogenesis
  • Piezo1 ion channels

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