TY - JOUR
T1 - Relationship of homocysteine to markers of platelet and endothelial activity in 'high risk' hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcome Trial
AU - Spencer, CGC
AU - Martin, SC
AU - Felmeden, DC
AU - Blann, Andrew
AU - Beevers, David
AU - Lip, Gregory
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Objective: To examine the relationship between plasma homocysteine (HCY) and theological, endothelial and platelet markers in 'high risk' hypertensive patients. Design: Cross-sectional study. Subjects and Methods: A total of 165 consecutive hypertensive patients (136 male; mean age 63 years (S.D. 8)) at high risk of cardiovascular disease who screened for inclusion in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) were studied along with 38 population normotensive healthy controls. We measured levels of plasma homocysteine [high pressure liquid chromatography (HPLC)], soluble P-selectin, a marker of platelet function, von Willebrand factor (vWF), an index of endothelial damage/dysfunction [both by ELISA] and fibrinogen (CLAUSS). The Framingham cardiovascular and cerebrovascular risk scores were calculated. Results: Hypertensives had significantly higher blood pressure (BP) [165/90(16/10) vs. 138/82(12/8) mm Hg, p <0.0001], sP-sel [54(44-67) vs. 45(35-57) ng/ml, p = 0.002], vWF [133(34) vs. 110(28) IU/dl, p <0.0001], and fibrinogen [2.98(2.523.47) vs. 2.43(2.20-2.83)g/l, p=
AB - Objective: To examine the relationship between plasma homocysteine (HCY) and theological, endothelial and platelet markers in 'high risk' hypertensive patients. Design: Cross-sectional study. Subjects and Methods: A total of 165 consecutive hypertensive patients (136 male; mean age 63 years (S.D. 8)) at high risk of cardiovascular disease who screened for inclusion in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) were studied along with 38 population normotensive healthy controls. We measured levels of plasma homocysteine [high pressure liquid chromatography (HPLC)], soluble P-selectin, a marker of platelet function, von Willebrand factor (vWF), an index of endothelial damage/dysfunction [both by ELISA] and fibrinogen (CLAUSS). The Framingham cardiovascular and cerebrovascular risk scores were calculated. Results: Hypertensives had significantly higher blood pressure (BP) [165/90(16/10) vs. 138/82(12/8) mm Hg, p <0.0001], sP-sel [54(44-67) vs. 45(35-57) ng/ml, p = 0.002], vWF [133(34) vs. 110(28) IU/dl, p <0.0001], and fibrinogen [2.98(2.523.47) vs. 2.43(2.20-2.83)g/l, p=
KW - von Willebrand factor
KW - hypertension
KW - soluble P-selectin
KW - homocysteine
UR - http://www.scopus.com/inward/record.url?scp=1842850650&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2003.06.002
DO - 10.1016/j.ijcard.2003.06.002
M3 - Article
C2 - 15093996
VL - 94
SP - 293
EP - 300
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -
