Relationship between V3 sequences of HIV type 1 from plasma, T cells, adn dendritic cells suggests taht plasma virus may arise from different cell sources

S Patterson, NR English, H Longhurst, P Jain, Peter Balfe, SC Knight

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nucleotide sequences of HIV-1 from plasma virus RNA and proviral DNA extracted from blood dendritic cells (DCs) and from T cells were analyzed to determine whether blood DCs may harbor a restricted population of virus variants. The sequence of the V3 loop and 51 bases from the 3' flanking region were determined in four patients not receiving antiviral therapy. There was no evidence of a unique or more restricted population of variants in DCs for any of the four patients studied. However, for one patient there was evidence of differences between plasma virus and virus in the T cell population, with virus in the plasma showing a closer relationship to DC-derived sequences.
Original languageEnglish
Pages (from-to)179-84
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume17
Issue number2
DOIs
Publication statusPublished - 1 Jan 2001

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