TY - JOUR
T1 - Relation of platelet activation to coronary angiographic severity and collateralization
AU - Tan, MT
AU - Tayebjee, Muzahir
AU - Macfadyen, Robert
AU - Lip, Gregory
PY - 2005/7/1
Y1 - 2005/7/1
N2 - We investigated whether platelet activation can be correlated with angiographic severity and the degree of collateralization in coronary artery disease (CAD), as well as endothelial damage/dysfunction. No studies have attempted to correlate platelet activation status, as measured by soluble plasma markers (soluble CD40 ligand, soluble P-selectin, soluble glycoprotein V), with the appearance of diseased coronary arteries. We found evidence of increased platelet activation in CAD, but a lack of correlation between the degree of platelet activation and the angiographic disease severity, which may reflect the presence of disease elsewhere or the presence of coronary atheroma not detected by angiography. (c) 2005 Elsevier Inc. All rights reserved.
AB - We investigated whether platelet activation can be correlated with angiographic severity and the degree of collateralization in coronary artery disease (CAD), as well as endothelial damage/dysfunction. No studies have attempted to correlate platelet activation status, as measured by soluble plasma markers (soluble CD40 ligand, soluble P-selectin, soluble glycoprotein V), with the appearance of diseased coronary arteries. We found evidence of increased platelet activation in CAD, but a lack of correlation between the degree of platelet activation and the angiographic disease severity, which may reflect the presence of disease elsewhere or the presence of coronary atheroma not detected by angiography. (c) 2005 Elsevier Inc. All rights reserved.
U2 - 10.1016/j.amjcard.2005.03.045
DO - 10.1016/j.amjcard.2005.03.045
M3 - Article
C2 - 16018843
SN - 1879-1913
VL - 96
SP - 208
EP - 210
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 2
ER -