Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D

Sarah Dimeloe, Alexandra Nanzer, Kimuli Ryanna, Catherine Hawrylowicz

Research output: Contribution to journalReview articlepeer-review

104 Citations (Scopus)

Abstract

Regulatory T cells (TRegs) play a central role in the maintenance of peripheral tolerance. They prevent inappropriate immune responses to ubiquitous allergens in healthy individuals, and contribute to the maintenance of immune homeostasis in the airways. Both Foxp3+ and IL-10+ TReg have been implicated in these functions. Glucocorticoids represent the mainstay of treatment for asthma and other allergic conditions, and evidence that steroids influence TReg function will be reviewed. Growing bodies of epidemiological and immunological data suggest a role for endogenous Vitamin D in immune regulation. This review will discuss the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma.

Original languageEnglish
Pages (from-to)86-95
Number of pages10
JournalThe Journal of Steroid Biochemistry and Molecular Biology
Volume120
Issue number2-3
DOIs
Publication statusPublished - 31 May 2010
Externally publishedYes

Keywords

  • Animals
  • Glucocorticoids
  • Humans
  • Hypersensitivity
  • Immune Tolerance
  • Inflammation
  • T-Lymphocytes, Regulatory
  • Vitamin D
  • Journal Article
  • Review

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