Abstract
Regulatory T cells (TRegs) play a central role in the maintenance of peripheral tolerance. They prevent inappropriate immune responses to ubiquitous allergens in healthy individuals, and contribute to the maintenance of immune homeostasis in the airways. Both Foxp3+ and IL-10+ TReg have been implicated in these functions. Glucocorticoids represent the mainstay of treatment for asthma and other allergic conditions, and evidence that steroids influence TReg function will be reviewed. Growing bodies of epidemiological and immunological data suggest a role for endogenous Vitamin D in immune regulation. This review will discuss the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma.
Original language | English |
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Pages (from-to) | 86-95 |
Number of pages | 10 |
Journal | The Journal of Steroid Biochemistry and Molecular Biology |
Volume | 120 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 31 May 2010 |
Externally published | Yes |
Keywords
- Animals
- Glucocorticoids
- Humans
- Hypersensitivity
- Immune Tolerance
- Inflammation
- T-Lymphocytes, Regulatory
- Vitamin D
- Journal Article
- Review