Regulatory opportunities to encourage technology solutions to antibacterial drug resistance

Roger Finch; BSAC Working Party on The Urgent Need: Regenerating Antibacterial Drug Discovery and Development; Laura Piddock

doi:10.1093/jac/dkr259

Regulatory opportunities to encourage technology solutions to antibacterial drug resistance

Roger Finch, BSAC Working Party on The Urgent Need: Regenerating Antibacterial Drug Discovery and Development, Laura Piddock

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Regulatory agencies play a critical role in the licensing of new antimicrobial agents. To address the pivotal role played by regulatory agencies, particularly in the context of a paucity of new drugs active against bacteria resistant to currently available drugs, the BSAC formed the 'Urgent Need' Working Party to address the regeneration of antibacterial drug discovery and development. The Working Party identified a number of issues, including: increased application of pharmacokinetic/pharmacodynamic principles to expedite drug development; the need to prioritize licensing of drugs (including 'orphan' drugs) active in life-threatening infections; and expansion of the use of surrogate markers and rapid point of care diagnostics to facilitate drug development.

Original language	English
Pages (from-to)	1945-7
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	66
Issue number	9
DOIs	https://doi.org/10.1093/jac/dkr259
Publication status	Published - Sept 2011

Keywords

Anti-Bacterial Agents
Bacterial Infections
Diffusion of Innovation
Drug Design
Drug Resistance, Bacterial
Humans
Legislation, Drug
Microbiology
Technology

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10.1093/jac/dkr259

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title = "Regulatory opportunities to encourage technology solutions to antibacterial drug resistance",

abstract = "Regulatory agencies play a critical role in the licensing of new antimicrobial agents. To address the pivotal role played by regulatory agencies, particularly in the context of a paucity of new drugs active against bacteria resistant to currently available drugs, the BSAC formed the 'Urgent Need' Working Party to address the regeneration of antibacterial drug discovery and development. The Working Party identified a number of issues, including: increased application of pharmacokinetic/pharmacodynamic principles to expedite drug development; the need to prioritize licensing of drugs (including 'orphan' drugs) active in life-threatening infections; and expansion of the use of surrogate markers and rapid point of care diagnostics to facilitate drug development.",

keywords = "Anti-Bacterial Agents, Bacterial Infections, Diffusion of Innovation, Drug Design, Drug Resistance, Bacterial, Humans, Legislation, Drug, Microbiology, Technology",

author = "Roger Finch and {BSAC Working Party on The Urgent Need: Regenerating Antibacterial Drug Discovery and Development} and Laura Piddock",

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KW - Anti-Bacterial Agents

KW - Bacterial Infections

KW - Diffusion of Innovation

KW - Drug Design

KW - Drug Resistance, Bacterial

KW - Humans

KW - Legislation, Drug

KW - Microbiology

KW - Technology

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SN - 0305-7453

VL - 66

SP - 1945

EP - 1947

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 9

ER -

Regulatory opportunities to encourage technology solutions to antibacterial drug resistance

Abstract

Keywords

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