Regulation of wingless transcription in the Drosophila embryo

P W Ingham, A Hidalgo

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)


The segment polarity gene wingless (wg) is expressed in a complex pattern during embryogenesis suggesting that it plays multiple roles in the development of the embryo. The best characterized of these is its role in cell pattening in each parasegment, a process that requires the activity of other segment polarity genes including patched (ptc) and hedgehog (hh). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show that most other aspects of wg expression are independent of this regulatory network.

Original languageEnglish
Pages (from-to)283-91
Number of pages9
JournalDevelopment (Cambridge)
Issue number1
Publication statusPublished - Jan 1993


  • Animals
  • Drosophila
  • Drosophila Proteins
  • Gene Expression Regulation
  • Genes, Insect
  • In Situ Hybridization
  • Proto-Oncogene Proteins
  • Signal Transduction
  • Transcription, Genetic
  • Wnt1 Protein
  • Journal Article
  • Research Support, Non-U.S. Gov't


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