Abstract
The segment polarity gene wingless (wg) is expressed in a complex pattern during embryogenesis suggesting that it plays multiple roles in the development of the embryo. The best characterized of these is its role in cell pattening in each parasegment, a process that requires the activity of other segment polarity genes including patched (ptc) and hedgehog (hh). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show that most other aspects of wg expression are independent of this regulatory network.
Original language | English |
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Pages (from-to) | 283-91 |
Number of pages | 9 |
Journal | Development (Cambridge) |
Volume | 117 |
Issue number | 1 |
Publication status | Published - Jan 1993 |
Keywords
- Animals
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Genes, Insect
- In Situ Hybridization
- Proto-Oncogene Proteins
- Signal Transduction
- Transcription, Genetic
- Wnt1 Protein
- Journal Article
- Research Support, Non-U.S. Gov't