Regulation of WASP: PIP2 Pipped by Toca-1?

Robert Insall; Laura Machesky

doi:10.1016/j.cell.2004.07.005

Regulation of WASP: PIP2 Pipped by Toca-1?

Robert Insall
, Laura Machesky

Biosciences

Research output: Contribution to journal › Review article

9 Citations (Scopus)

Abstract

Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.

Original language	English
Pages (from-to)	140-1
Number of pages	2
Journal	Cell
Volume	118
DOIs	https://doi.org/10.1016/j.cell.2004.07.005
Publication status	Published - 1 Jan 2004

Access to Document

10.1016/j.cell.2004.07.005

Fellowship: Dr L Machesky - The Arp2/3 Complex in Actin- Based Motility.
Machesky, L. (Principal Investigator)
Medical Research Council
1/10/00 → 30/09/05
Project: Research Councils

Cite this

@article{3bdc7fa5ee524e44a44a0eafdcfdf909,

title = "Regulation of WASP: PIP2 Pipped by Toca-1?",

abstract = "Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.",

author = "Robert Insall and Laura Machesky",

year = "2004",

month = jan,

day = "1",

doi = "10.1016/j.cell.2004.07.005",

language = "English",

volume = "118",

pages = "140--1",