Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases

N A Hotchin; A Hall

Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases

N A Hotchin
, A Hall

Biosciences

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.

Original language	English
Pages (from-to)	311-22
Number of pages	12
Journal	Cancer surveys
Volume	27
Publication status	Published - 1996

Cite this

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title = "Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases",

abstract = "The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.",

author = "Hotchin, \{N A\} and A Hall",

year = "1996",

language = "English",

volume = "27",

pages = "311--22",

journal = "Cancer surveys",

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T1 - Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases

AU - Hotchin, N A

AU - Hall, A

PY - 1996

Y1 - 1996

N2 - The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.

AB - The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.

M3 - Article

C2 - 8909807

SN - 0261-2429

VL - 27

SP - 311

EP - 322

JO - Cancer surveys

JF - Cancer surveys

ER -

Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases

Abstract

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