Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

Natasha Weston; Prateek Sharma; Vito Ricci; Laura J V Piddock

doi:10.1016/j.resmic.2017.10.005

Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

Natasha Weston, Prateek Sharma, Vito Ricci, Laura J V Piddock

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Abstract

Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.

Original language	English
Journal	Research in Microbiology
Early online date	8 Nov 2017
DOIs	https://doi.org/10.1016/j.resmic.2017.10.005
Publication status	E-pub ahead of print - 8 Nov 2017

Keywords

Salmonella
Escherichia coli
AcrAB-TolC
Transcription
Induction
Multidrug resistance

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10.1016/j.resmic.2017.10.005Licence: None: All rights reserved

Weston_et_al_Regulation_of_the_AcrAB-TolC_efflux_pump_Research_in_Microbiology_2017Accepted author manuscript, 238 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

http://www.sciencedirect.com/science/article/pii/S0923250817301766Licence: None: All rights reserved

Unravelling the Network of Regulation of Multidrug Resistance in Salmonella Enterica
Piddock, L. (Principal Investigator) & Busby, S. (Co-Investigator)
Medical Research Council
1/05/09 → 31/12/14
Project: Research Councils
Unravelling Multiple Antibiotic Resistance in Salmonella Enterica
Piddock, L. (Principal Investigator)
Medical Research Council
1/04/06 → 31/03/09
Project: Research Councils

Cite this

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title = "Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae",

abstract = "Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.",

keywords = "Salmonella, Escherichia coli, AcrAB-TolC, Transcription, Induction, Multidrug resistance",

author = "Natasha Weston and Prateek Sharma and Vito Ricci and Piddock, {Laura J V}",

note = "Copyright {\textcopyright} 2017. Published by Elsevier Masson SAS.",

year = "2017",

month = nov,

day = "8",

doi = "10.1016/j.resmic.2017.10.005",

language = "English",

journal = "Research in Microbiology",

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T1 - Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

AU - Weston, Natasha

AU - Sharma, Prateek

AU - Ricci, Vito

AU - Piddock, Laura J V

PY - 2017/11/8

Y1 - 2017/11/8

N2 - Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.

AB - Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.

KW - Salmonella

KW - Escherichia coli

KW - AcrAB-TolC

KW - Transcription

KW - Induction

KW - Multidrug resistance

U2 - 10.1016/j.resmic.2017.10.005

DO - 10.1016/j.resmic.2017.10.005

M3 - Article

C2 - 29128373

SN - 0923-2508

JO - Research in Microbiology

JF - Research in Microbiology

ER -

Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

Abstract

Keywords

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Projects

Unravelling the Network of Regulation of Multidrug Resistance in Salmonella Enterica

Unravelling Multiple Antibiotic Resistance in Salmonella Enterica

Cite this