Regulation of ELAV/Hu RNA-binding proteins by phosphorylation

Ulrike Brauer; Emanuela Zaharieva; Matthias Soller

doi:10.1042/BST20140103

Regulation of ELAV/Hu RNA-binding proteins by phosphorylation

Ulrike Brauer, Emanuela Zaharieva, Matthias Soller

Biosciences

Research output: Contribution to journal › Conference article

3 Citations (Scopus)

Abstract

ELAV (embryonic lethal/abnormal visual system)/Hu proteins comprise a family of highly related neuronal RBPs (RNA-binding proteins) involved in many aspects of mRNA processing. Although they bind to highly similar short sequence motifs, they have acquired diverse functions suggesting that cellular signalling is important for their functional diversification. Indeed, ELAV/Hu proteins harbour many phosphorylatable amino acids. In the present article, we review our current knowledge about phosphorylation of ELAV/Hu proteins and how phosphorylation affects cellular localization of ELAV/Hu proteins and their binding to RNA.

Original language	English
Pages (from-to)	1147-1151
Number of pages	5
Journal	Biochemical Society Transactions
Volume	42
Issue number	4
DOIs	https://doi.org/10.1042/BST20140103
Publication status	Published - 11 Aug 2014

Keywords

alternative splicing
ELAV/Hu family proteins
nucleocytoplasmic shuttling
phosphorylation
RNA-binding protein

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@article{b366eb9e379e4975bcb22164a86d00cf,

title = "Regulation of ELAV/Hu RNA-binding proteins by phosphorylation",

abstract = "ELAV (embryonic lethal/abnormal visual system)/Hu proteins comprise a family of highly related neuronal RBPs (RNA-binding proteins) involved in many aspects of mRNA processing. Although they bind to highly similar short sequence motifs, they have acquired diverse functions suggesting that cellular signalling is important for their functional diversification. Indeed, ELAV/Hu proteins harbour many phosphorylatable amino acids. In the present article, we review our current knowledge about phosphorylation of ELAV/Hu proteins and how phosphorylation affects cellular localization of ELAV/Hu proteins and their binding to RNA.",

keywords = "alternative splicing, ELAV/Hu family proteins, nucleocytoplasmic shuttling, phosphorylation, RNA-binding protein",

author = "Ulrike Brauer and Emanuela Zaharieva and Matthias Soller",

year = "2014",

month = aug,

day = "11",

doi = "10.1042/BST20140103",

language = "English",

volume = "42",

pages = "1147--1151",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press",

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TY - JOUR

T1 - Regulation of ELAV/Hu RNA-binding proteins by phosphorylation

AU - Brauer, Ulrike

AU - Zaharieva, Emanuela

AU - Soller, Matthias

PY - 2014/8/11

Y1 - 2014/8/11

N2 - ELAV (embryonic lethal/abnormal visual system)/Hu proteins comprise a family of highly related neuronal RBPs (RNA-binding proteins) involved in many aspects of mRNA processing. Although they bind to highly similar short sequence motifs, they have acquired diverse functions suggesting that cellular signalling is important for their functional diversification. Indeed, ELAV/Hu proteins harbour many phosphorylatable amino acids. In the present article, we review our current knowledge about phosphorylation of ELAV/Hu proteins and how phosphorylation affects cellular localization of ELAV/Hu proteins and their binding to RNA.

AB - ELAV (embryonic lethal/abnormal visual system)/Hu proteins comprise a family of highly related neuronal RBPs (RNA-binding proteins) involved in many aspects of mRNA processing. Although they bind to highly similar short sequence motifs, they have acquired diverse functions suggesting that cellular signalling is important for their functional diversification. Indeed, ELAV/Hu proteins harbour many phosphorylatable amino acids. In the present article, we review our current knowledge about phosphorylation of ELAV/Hu proteins and how phosphorylation affects cellular localization of ELAV/Hu proteins and their binding to RNA.

KW - alternative splicing

KW - ELAV/Hu family proteins

KW - nucleocytoplasmic shuttling

KW - phosphorylation

KW - RNA-binding protein

U2 - 10.1042/BST20140103

DO - 10.1042/BST20140103

M3 - Conference article

SN - 0300-5127

VL - 42

SP - 1147

EP - 1151

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

Regulation of ELAV/Hu RNA-binding proteins by phosphorylation

Abstract

Keywords

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