Regulation and roles of Ca2+ stores in human sperm

Joao Correia, Francesco Michelangeli, Stephen Publicover

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)
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[Ca(2)(+)]i signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2)(+)-permeable plasma membrane ion channel CatSper is central to [Ca(2)(+)]i signalling, but there is good evidence that Ca(2)(+) stored in intracellular organelles is also functionally important. Here we briefly review the current understanding of the diversity of Ca(2)(+) stores and the mechanisms for the regulation of their activity. We then consider the evidence for the involvement of these stores in [Ca(2)(+)]i signalling in mammalian (primarily human) sperm, the agonists that may activate these stores and their role in control of sperm function. Finally we consider the evidence that membrane Ca(2)(+) channels and stored Ca(2)(+) may play discrete roles in the regulation of sperm activities and propose a mechanism by which these different components of the sperm Ca(2)(+)-signalling apparatus may interact to generate complex and spatially diverse [Ca(2)(+)]i signals.

Original languageEnglish
Pages (from-to)R65-R76
Issue number2
Early online date11 May 2015
Publication statusPublished - 1 Aug 2015

Bibliographical note

© 2015 The authors.


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