Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following toll-like receptor 2 Stimulation in THP-1 monocytes

Eng Kiat Lim; Paul J. Mitchell; Najmeeyah Brown; Rebecca A. Drummond; Gordon D. Brown; Paul M. Kaye; Dianna J. Bowles

doi:10.1074/jbc.M113.453514

Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following toll-like receptor 2 Stimulation in THP-1 monocytes

Eng Kiat Lim, Paul J. Mitchell, Najmeeyah Brown, Rebecca A. Drummond, Gordon D. Brown, Paul M. Kaye^*, Dianna J. Bowles

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: Plant natural products typically contain regiospecific modifications in their side chains that lead to different bioactivities. Results: Only 3-O-methylated flavonols enhance IL-1β production in THP-1 cells costimulated with the Toll-like receptor 2 agonist Pam3CSK4. Conclusion: Regiospecific methylation of flavonols controls their bioactivity as immunomodulators. Significance: This study provides a platform to explore the use of regiospecific-modified natural products as novel immunomodulators.

Original language	English
Pages (from-to)	21126-21135
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M113.453514
Publication status	Published - 19 Jul 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.453514

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@article{9788cb6c9c9440bd97ac256728398800,

title = "Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following toll-like receptor 2 Stimulation in THP-1 monocytes",

abstract = "Background: Plant natural products typically contain regiospecific modifications in their side chains that lead to different bioactivities. Results: Only 3-O-methylated flavonols enhance IL-1β production in THP-1 cells costimulated with the Toll-like receptor 2 agonist Pam3CSK4. Conclusion: Regiospecific methylation of flavonols controls their bioactivity as immunomodulators. Significance: This study provides a platform to explore the use of regiospecific-modified natural products as novel immunomodulators.",

author = "Lim, {Eng Kiat} and Mitchell, {Paul J.} and Najmeeyah Brown and Drummond, {Rebecca A.} and Brown, {Gordon D.} and Kaye, {Paul M.} and Bowles, {Dianna J.}",

year = "2013",

month = jul,

day = "19",

doi = "10.1074/jbc.M113.453514",

language = "English",

volume = "288",

pages = "21126--21135",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology",

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}

Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following toll-like receptor 2 Stimulation in THP-1 monocytes. / Lim, Eng Kiat; Mitchell, Paul J.; Brown, Najmeeyah et al.
In: Journal of Biological Chemistry, Vol. 288, No. 29, 19.07.2013, p. 21126-21135.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following toll-like receptor 2 Stimulation in THP-1 monocytes

AU - Lim, Eng Kiat

AU - Mitchell, Paul J.

AU - Brown, Najmeeyah

AU - Drummond, Rebecca A.

AU - Brown, Gordon D.

AU - Kaye, Paul M.

AU - Bowles, Dianna J.

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: Plant natural products typically contain regiospecific modifications in their side chains that lead to different bioactivities. Results: Only 3-O-methylated flavonols enhance IL-1β production in THP-1 cells costimulated with the Toll-like receptor 2 agonist Pam3CSK4. Conclusion: Regiospecific methylation of flavonols controls their bioactivity as immunomodulators. Significance: This study provides a platform to explore the use of regiospecific-modified natural products as novel immunomodulators.

AB - Background: Plant natural products typically contain regiospecific modifications in their side chains that lead to different bioactivities. Results: Only 3-O-methylated flavonols enhance IL-1β production in THP-1 cells costimulated with the Toll-like receptor 2 agonist Pam3CSK4. Conclusion: Regiospecific methylation of flavonols controls their bioactivity as immunomodulators. Significance: This study provides a platform to explore the use of regiospecific-modified natural products as novel immunomodulators.

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DO - 10.1074/jbc.M113.453514

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AN - SCOPUS:84880550807

SN - 0021-9258

VL - 288

SP - 21126

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 29

ER -

Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following toll-like receptor 2 Stimulation in THP-1 monocytes

Abstract

ASJC Scopus subject areas

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