Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

Derville O'Shea; Ciarán O'Riain; Manu Gupta; Rachel Waters; Youwen Yang; David Wrench; John Gribben; Andreas Rosenwald; German Ott; Lisa M Rimsza; Harald Holte; Jean-Baptiste Cazier; Nathalie A Johnson; Elias Campo; Wing C Chan; Randy D Gascoyne; Bryan D Young; Louis M Staudt; T Andrew Lister; Jude Fitzgibbon

doi:10.1182/blood-2008-08-174953

Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

Derville O'Shea, Ciarán O'Riain, Manu Gupta, Rachel Waters, Youwen Yang, David Wrench, John Gribben, Andreas Rosenwald, German Ott, Lisa M Rimsza, Harald Holte, Jean-Baptiste Cazier, Nathalie A Johnson, Elias Campo, Wing C Chan, Randy D Gascoyne, Bryan D Young, Louis M Staudt, T Andrew Lister, Jude Fitzgibbon

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P < .03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P = .05). aUPD on 16p was predictive of transformation (P = .03) and correlated with poorer progression-free survival (P = .02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome.

Original language	English
Pages (from-to)	2298-301
Number of pages	4
Journal	Blood
Volume	113
Issue number	10
DOIs	https://doi.org/10.1182/blood-2008-08-174953
Publication status	Published - 5 Mar 2009

Keywords

Cell Transformation, Neoplastic
DNA Mutational Analysis
Disease-Free Survival
Humans
Kaplan-Meier Estimate
Loss of Heterozygosity
Lymphoma, Follicular
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide
Risk Factors
Uniparental Disomy

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10.1182/blood-2008-08-174953

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O'Shea, D., O'Riain, C., Gupta, M., Waters, R., Yang, Y., Wrench, D., Gribben, J., Rosenwald, A., Ott, G., Rimsza, L. M., Holte, H., Cazier, J-B., Johnson, N. A., Campo, E., Chan, W. C., Gascoyne, R. D., Young, B. D., Staudt, L. M., Lister, T. A., & Fitzgibbon, J. (2009). Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. Blood, 113(10), 2298-301. https://doi.org/10.1182/blood-2008-08-174953

@article{f0d3e15d00844a68b28da02d748618c8,

title = "Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation",

abstract = "Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P < .03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P = .05). aUPD on 16p was predictive of transformation (P = .03) and correlated with poorer progression-free survival (P = .02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome.",

keywords = "Cell Transformation, Neoplastic, DNA Mutational Analysis, Disease-Free Survival, Humans, Kaplan-Meier Estimate, Loss of Heterozygosity, Lymphoma, Follicular, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Risk Factors, Uniparental Disomy",

author = "Derville O'Shea and Ciar{\'a}n O'Riain and Manu Gupta and Rachel Waters and Youwen Yang and David Wrench and John Gribben and Andreas Rosenwald and German Ott and Rimsza, {Lisa M} and Harald Holte and Jean-Baptiste Cazier and Johnson, {Nathalie A} and Elias Campo and Chan, {Wing C} and Gascoyne, {Randy D} and Young, {Bryan D} and Staudt, {Louis M} and Lister, {T Andrew} and Jude Fitzgibbon",

year = "2009",

month = mar,

day = "5",

doi = "10.1182/blood-2008-08-174953",

language = "English",

volume = "113",

pages = "2298--301",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

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O'Shea, D, O'Riain, C, Gupta, M, Waters, R, Yang, Y, Wrench, D, Gribben, J, Rosenwald, A, Ott, G, Rimsza, LM, Holte, H, Cazier, J-B, Johnson, NA, Campo, E, Chan, WC, Gascoyne, RD, Young, BD, Staudt, LM, Lister, TA & Fitzgibbon, J 2009, 'Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation', Blood, vol. 113, no. 10, pp. 2298-301. https://doi.org/10.1182/blood-2008-08-174953

TY - JOUR

T1 - Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

AU - O'Shea, Derville

AU - O'Riain, Ciarán

AU - Gupta, Manu

AU - Waters, Rachel

AU - Yang, Youwen

AU - Wrench, David

AU - Gribben, John

AU - Rosenwald, Andreas

AU - Ott, German

AU - Rimsza, Lisa M

AU - Holte, Harald

AU - Cazier, Jean-Baptiste

AU - Johnson, Nathalie A

AU - Campo, Elias

AU - Chan, Wing C

AU - Gascoyne, Randy D

AU - Young, Bryan D

AU - Staudt, Louis M

AU - Lister, T Andrew

AU - Fitzgibbon, Jude

PY - 2009/3/5

Y1 - 2009/3/5

N2 - Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P < .03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P = .05). aUPD on 16p was predictive of transformation (P = .03) and correlated with poorer progression-free survival (P = .02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome.

AB - Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P < .03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P = .05). aUPD on 16p was predictive of transformation (P = .03) and correlated with poorer progression-free survival (P = .02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome.

KW - Cell Transformation, Neoplastic

KW - DNA Mutational Analysis

KW - Disease-Free Survival

KW - Humans

KW - Kaplan-Meier Estimate

KW - Loss of Heterozygosity

KW - Lymphoma, Follicular

KW - Oligonucleotide Array Sequence Analysis

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Uniparental Disomy

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-64049088845&partnerID=MN8TOARS

U2 - 10.1182/blood-2008-08-174953

DO - 10.1182/blood-2008-08-174953

M3 - Article

C2 - 19141865

SN - 0006-4971

VL - 113

SP - 2298

EP - 2301

JO - Blood

JF - Blood

IS - 10

ER -

Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

Abstract

Keywords

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