Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

M Nassimisadeh; H Ashrafian; Nigel Drury; Neil Howell; J Digby; Domenico Pagano; MP Frenneaux; GVR Born

doi:10.1177/1479164110376207

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

M Nassimisadeh, H Ashrafian, Nigel Drury, Neil Howell, J Digby, Domenico Pagano, MP Frenneaux, GVR Born

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Abstract

Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.

Original language	English
Pages (from-to)	213-215
Number of pages	3
Journal	Diabetes and Vascular Disease Research
Volume	7
Issue number	3
DOIs	https://doi.org/10.1177/1479164110376207
Publication status	Published - 1 Jul 2010

Keywords

type 2 diabetes mellitus
negative surface charge
Arterial endothelium
atherosclerosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1479164110376207

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abstract = "Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.",

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AU - Nassimisadeh, M

AU - Ashrafian, H

AU - Drury, Nigel

AU - Howell, Neil

AU - Digby, J

AU - Pagano, Domenico

AU - Frenneaux, MP

AU - Born, GVR

PY - 2010/7/1

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N2 - Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.

AB - Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.

KW - type 2 diabetes mellitus

KW - negative surface charge

KW - Arterial endothelium

KW - atherosclerosis

U2 - 10.1177/1479164110376207

DO - 10.1177/1479164110376207

M3 - Article

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JO - Diabetes and Vascular Disease Research

JF - Diabetes and Vascular Disease Research

IS - 3

ER -

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Abstract

Keywords

UN SDGs

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