Recommendations to promote equity, diversity and inclusion in decentralized clinical trials

Olalekan Lee Aiyegbusi; Samantha Cruz Rivera; Paul Kamudoni; Nicola Anderson; Philip  Collis; Alastair K. Denniston; Rosie Harding; Sarah E. Hughes; Kamlesh K Khunti; Dipak Kotecha; Harlan Krumholz; Xiaoxuan Liu; Christel McMullan; Barbara  Molony-Oates; Joao  Monteiro; Puja Myles; Khadija Rerhou Rantell; Katherine Soltys; Ravinder  Verdi; Roger  Wilson; Melanie J. Calvert

doi:10.1038/s41591-024-03323-w

Recommendations to promote equity, diversity and inclusion in decentralized clinical trials

Olalekan Lee Aiyegbusi^*, Samantha Cruz Rivera, Paul Kamudoni, Nicola Anderson, Philip Collis, Alastair K. Denniston, Rosie Harding, Sarah E. Hughes, Kamlesh K Khunti, Dipak Kotecha, Harlan Krumholz, Xiaoxuan Liu, Christel McMullan, Barbara Molony-Oates, Joao Monteiro, Puja Myles, Khadija Rerhou Rantell, Katherine Soltys, Ravinder Verdi, Roger WilsonMelanie J. Calvert

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. The rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer, and store electronic data. Whilst some studies demonstrate the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges which may create or worsen existing health inequalities and limit the generalizability of trial results. Here, we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity, and inclusion.

Original language	English
Journal	Nature Medicine
Early online date	29 Oct 2024
DOIs	https://doi.org/10.1038/s41591-024-03323-w
Publication status	E-pub ahead of print - 29 Oct 2024

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Aiyegbusi, O. L., Cruz Rivera, S., Kamudoni, P., Anderson, N., Collis, P., Denniston, A. K., Harding, R., Hughes, S. E., Khunti, K. K., Kotecha, D., Krumholz, H., Liu, X., McMullan, C., Molony-Oates, B., Monteiro, J., Myles, P., Rantell, K. R., Soltys, K., Verdi, R., ... Calvert, M. J. (2024). Recommendations to promote equity, diversity and inclusion in decentralized clinical trials. Nature Medicine. Advance online publication. https://doi.org/10.1038/s41591-024-03323-w

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abstract = "Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. The rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer, and store electronic data. Whilst some studies demonstrate the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges which may create or worsen existing health inequalities and limit the generalizability of trial results. Here, we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity, and inclusion.",

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Aiyegbusi, OL , Cruz Rivera, S, Kamudoni, P, Anderson, N, Collis, P, Denniston, AK , Harding, R , Hughes, SE, Khunti, KK, Kotecha, D, Krumholz, H, Liu, X , McMullan, C, Molony-Oates, B, Monteiro, J, Myles, P, Rantell, KR, Soltys, K, Verdi, R, Wilson, R & Calvert, MJ 2024, 'Recommendations to promote equity, diversity and inclusion in decentralized clinical trials', Nature Medicine. https://doi.org/10.1038/s41591-024-03323-w

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T1 - Recommendations to promote equity, diversity and inclusion in decentralized clinical trials

AU - Aiyegbusi, Olalekan Lee

AU - Cruz Rivera, Samantha

AU - Kamudoni, Paul

AU - Anderson, Nicola

AU - Collis, Philip

AU - Denniston, Alastair K.

AU - Harding, Rosie

AU - Hughes, Sarah E.

AU - Khunti, Kamlesh K

AU - Kotecha, Dipak

AU - Krumholz, Harlan

AU - Liu, Xiaoxuan

AU - McMullan, Christel

AU - Molony-Oates, Barbara

AU - Monteiro, Joao

AU - Myles, Puja

AU - Rantell, Khadija Rerhou

AU - Soltys, Katherine

AU - Verdi, Ravinder

AU - Wilson, Roger

AU - Calvert, Melanie J.

PY - 2024/10/29

Y1 - 2024/10/29

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AB - Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. The rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer, and store electronic data. Whilst some studies demonstrate the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges which may create or worsen existing health inequalities and limit the generalizability of trial results. Here, we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity, and inclusion.

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M3 - Article

SN - 1078-8956

JO - Nature Medicine

JF - Nature Medicine

ER -

Recommendations to promote equity, diversity and inclusion in decentralized clinical trials

Abstract

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