Recognition-Mediated Regiocontrol of a Dipolar Cycloaddition Reaction

SJ Howell, Neil Spencer, Douglas Philp

Research output: Contribution to journalArticle

59 Citations (Scopus)


The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized-using molecular mechanics calculations-in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4945-4954
Number of pages10
Issue number23
Publication statusPublished - 4 Jun 2001


  • cycloaddition
  • molecular recognition
  • azides
  • kinetics


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