Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557)

David E Minnikin; Oona Y-c Lee; Houdini Ht Wu; Gurdyal S Besra; Helen D Donoghue

doi:10.1177/0959683619895572

Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557)

David E Minnikin, Oona Y-c Lee, Houdini Ht Wu, Gurdyal S Besra, Helen D Donoghue

Biosciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.

Original language	English
Pages (from-to)	781-783
Number of pages	3
Journal	The Holocene
Volume	30
Issue number	5
Early online date	5 Jan 2020
DOIs	https://doi.org/10.1177/0959683619895572
Publication status	Published - 1 May 2020

Keywords

DNA fragment amplification
Pleistocene megafauna
ancient tuberculosis
genomes
lipid biomarkers
paleopathology
tuberculosis evolution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/0959683619895572Licence: None: All rights reserved

http://journals.sagepub.com/doi/10.1177/0959683619895572Licence: None: All rights reserved

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Minnikin, D. E., Lee, O. Y., Wu, H. H., Besra, G. S., & Donoghue, H. D. (2020). Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557) The Holocene, 30(5), 781-783. https://doi.org/10.1177/0959683619895572

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abstract = "The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.",

keywords = "DNA fragment amplification, Pleistocene megafauna, ancient tuberculosis, genomes, lipid biomarkers, paleopathology, tuberculosis evolution",

author = "Minnikin, {David E} and Lee, {Oona Y-c} and Wu, {Houdini Ht} and Besra, {Gurdyal S} and Donoghue, {Helen D}",

year = "2020",

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Minnikin, DE, Lee, OY, Wu, HH, Besra, GS & Donoghue, HD 2020, 'Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557) ', The Holocene, vol. 30, no. 5, pp. 781-783. https://doi.org/10.1177/0959683619895572

Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557) . / Minnikin, David E; Lee, Oona Y-c; Wu, Houdini Ht et al.
In: The Holocene, Vol. 30, No. 5, 01.05.2020, p. 781-783.

Research output: Contribution to journal › Comment/debate › peer-review

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AU - Besra, Gurdyal S

AU - Donoghue, Helen D

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AB - The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.

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KW - Pleistocene megafauna

KW - ancient tuberculosis

KW - genomes

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