Recent Progress in Antithrombotic Therapy for Atrial Fibrillation

S Velu, Gregory Lip

Research output: Contribution to journalReview article

4 Citations (Scopus)


Atrial fibrillation (AF) is becoming a major health care burden as elderly populations increase. The increased risk of stroke and thromboembolisms in patients with AF is well documented and anticoagulation with adjusted-dose warfarin is highly effective in reducing stroke risk, being superior to antiplatelet agents. Despite recognition of the epidemiological problem and the sound evidence base for thromboprophylaxis, as well as major guidelines recommending treatment, anticoagulation use is still suboptimal, given the dis-utility and limitations associated with warfarin. Recent developments in thromboprophylaxis for AF include efforts for better risk stratification for predictions of thromboembolic risk. Constant efforts are underway to develop newer, less cumbersome, alternatives to warfarin with similar (or better) efficacy. This review article provides an overview of the recent progress made, the potential challenges involved and the future of these therapeutic approaches.
Original languageEnglish
Pages (from-to)257-273
Number of pages17
JournalJournal of atherosclerosis and thrombosis
Issue number4
Publication statusPublished - 1 Jan 2011


  • Direct Thrombin Inhibitors
  • CHADS(2)
  • Stroke
  • CHA(2)DS(2)VASC
  • Oral antithrombotic therapy
  • Newer antithrombotic agents
  • Factor Xa inhibitors
  • Warfarin
  • Atrial Fibrillation
  • Thromboembolism


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