Recent advances in non-optical microfluidic platforms for bioparticle detection

Bayinqiaoge, Yuxin Zhang, Tim Cole, Jiahao Zheng, Jinhong Guo, Shi-Yang Tang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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The effective analysis of the basic structure and functional information of bioparticles are of great significance for the early diagnosis of diseases. The synergism between microfluidics and particle manipulation/detection technologies offers enhanced system integration capability and test accuracy for the detection of various bioparticles. Most microfluidic detection platforms are based on optical strategies such as fluorescence, absorbance, and image recognition. Although optical microfluidic platforms have proven their capabilities in the practical clinical detection of bioparticles, shortcomings such as expensive components and whole bulky devices have limited their practicality in the development of point-of-care testing (POCT) systems to be used in remote and underdeveloped areas. Therefore, there is an urgent need to develop cost-effective non-optical microfluidic platforms for bioparticle detection that can act as alternatives to optical counterparts. In this review, we first briefly summarise passive and active methods for bioparticle manipulation in microfluidics. Then, we survey the latest progress in non-optical microfluidic strategies based on electrical, magnetic, and acoustic techniques for bioparticle detection. Finally, a perspective is offered, clarifying challenges faced by current non-optical platforms in developing practical POCT devices and clinical applications.

Original languageEnglish
Article number114944
Number of pages17
JournalBiosensors and Bioelectronics
Early online date30 Nov 2022
Publication statusPublished - 15 Feb 2023

Bibliographical note

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.


  • Microfluidics/methods
  • Biosensing Techniques
  • Point-of-Care Testing
  • Point-of-Care Systems
  • Microfluidic Analytical Techniques
  • Lab-On-A-Chip Devices


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