Real-time trace detection and identification of chemical warfare agent simulants using recent advances in proton transfer reaction time-of-flight mass spectrometry

F Petersson, P Sulzer, Christopher Mayhew, Peter Watts, A Jordan, L Maerk, TD Maerk

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

This work demonstrates for the first time the potential of using recent developments in proton transfer reaction mass spectrometry for the rapid detection and identification of chemical warfare agents (CWAs) in real-time. A high-resolution (m/Delta m up to 8000) and high-sensitivity (similar to 50 cps/ppbv) proton transfer reaction time-of-flight mass spectrometer (PTR-TOF 8000 from Ionicon Analytik GmBH) has been successfully used to detect a number of CWA simulants at room temperature; namely dimethyl methylphosphonate, diethyl methylphosphonate, diisopropyl methylphosphonate, dipropylene glycol monomethyl ether and 2-chloroethyl ethyl sulfide. Importantly, we demonstrate in this paper the potential to identify CWAs with a high level of confidence in complex chemical environments, where multiple threat agents and interferents could also be present in trace amounts, thereby reducing the risk of false positives. Instantaneous detection and identification of trace quantities of chemical threats using proton transfer reaction mass spectrometry could form the basis for a timely warning system capability with greater precision and accuracy than is currently provided by existing analytical technologies. Copyright (C) 2009 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)3875-3880
Number of pages6
JournalRapid Communications in Mass Spectrometry
Volume23
Issue number23
DOIs
Publication statusPublished - 1 Dec 2009

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