TY - JOUR
T1 - Real-Time Observation of "soft" Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
AU - Szczerba, Daniel
AU - Tan, Davin
AU - Do, Jean Louis
AU - Titi, Hatem M.
AU - Mouhtadi, Siham
AU - Chaumont, Denis
AU - Del Carmen Marco De Lucas, María
AU - Geoffroy, Nicolas
AU - Meyer, Michel
AU - Rousselin, Yoann
AU - Hudspeth, Jessica M.
AU - Schwanen, Valérie
AU - Spoerk-Erdely, Petra
AU - Dippel, Ann Christin
AU - Ivashko, Oleh
AU - Gutowski, Olof
AU - Glaevecke, Philipp
AU - Bazhenov, Vasilii
AU - Arhangelskis, Mihails
AU - Halasz, Ivan
AU - Friščić, Tomislav
AU - Kimber, Simon A.J.
PY - 2021/10/13
Y1 - 2021/10/13
N2 - Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size" clusters can be both stable enough to crystallize and sufficiently labile for further growth.
AB - Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size" clusters can be both stable enough to crystallize and sufficiently labile for further growth.
UR - https://www.scopus.com/pages/publications/85117249174
U2 - 10.1021/jacs.1c07186
DO - 10.1021/jacs.1c07186
M3 - Article
C2 - 34582201
AN - SCOPUS:85117249174
SN - 0002-7863
VL - 143
SP - 16332
EP - 16336
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 40
ER -