Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

Marie Schaeffer, Fanny Langlet, Chrystel Lafont, François Molino, David J Hodson, Thomas Roux, Laurent Lamarque, Pascal Verdié, Emmanuel Bourrier, Bénédicte Dehouck, Jean-Louis Banères, Jean Martinez, Pierre-François Méry, Jacky Marie, Eric Trinquet, Jean-Alain Fehrentz, Vincent Prévot, Patrice Mollard

Research output: Contribution to journalArticlepeer-review

170 Citations (Scopus)


To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.

Original languageEnglish
Pages (from-to)1512-7
Number of pages6
JournalNational Academy of Sciences. Proceedings
Issue number4
Publication statusPublished - 22 Jan 2013


  • Animals
  • Appetite Regulation
  • Blood-Brain Barrier
  • Capillary Permeability
  • Eating
  • Fasting
  • Ghrelin
  • Hypothalamus
  • Male
  • Median Eminence
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microscopy, Fluorescence, Multiphoton
  • Models, Neurological
  • Neurons


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